proza protein Z, vitamin K-dependent plasma glycoprotein a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prozaprovided by ZNC
Official Full Name: protein Z, vitamin K-dependent plasma glycoprotein aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061013-403
See related: Ensembl:ENSDARG00000037783 AllianceGenome:ZFIN:ZDB-GENE-061013-403
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj51g06; zgc:152997
Summary: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within blood coagulation and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (62382661..62393457, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (62146031..62156827, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj08b07.y1 (e-PCR)
- UniSTS:198456

fj51g06.x1 (e-PCR)
- UniSTS:188652

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Z, vitamin K-dependent plasma glycoprotein a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327792.1 → NP_001314721.1 protein Z, vitamin K-dependent plasma glycoprotein a precursor

Status: VALIDATED

Source sequence(s)

BX470259

UniProtKB/TrEMBL

A0A8M1P8A5, F1Q5S2

Related

ENSDARP00000156930.1, ENSDART00000181704.1

Conserved Domains (5) summary

smart00069
Location:28 → 90

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:91 → 127

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00089
Location:199 → 420

Trypsin; Trypsin

pfam14670
Location:140 → 164

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl21584
Location:199 → 423

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

62382661..62393457 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394544.1 Reference GRCz11 ALT_DRER_TU_1

Range

208272..219068 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001077319.1: Suppressed sequence

Description

NM_001077319.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.