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    si:ch211-114l13.1 si:ch211-114l13.1 [ Danio rerio (zebrafish) ]

    Gene ID: 566121, updated on 11-Apr-2024

    Summary

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    Official Symbol
    si:ch211-114l13.1provided by ZNC
    Official Full Name
    si:ch211-114l13.1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-109
    See related
    Ensembl:ENSDARG00000093323 AllianceGenome:ZFIN:ZDB-GENE-070424-109
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in several diseases, including CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP13 (NLR family pyrin domain containing 13); NLRP14 (NLR family pyrin domain containing 14); and NLRP2 (NLR family pyrin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See si:ch211-114l13.1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (58091640..58103125)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (57355977..57367443)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene caspase b Neighboring gene si:ch211-114l13.13 Neighboring gene NLR family, CARD domain containing 10 Neighboring gene si:ch211-15j1.5 Neighboring gene caspase b, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NLRC3
    Names
    NOD-like receptor C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      58091640..58103125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160210.4 → XP_005160267.1  protein NLRC3

      UniProtKB/TrEMBL
      A0A8M2B723, F1R020
      Related
      ENSDARP00000113293.2, ENSDART00000144190.4
      Conserved Domains (5) summary
      sd00031
      Location:696 → 724
      LRR_1; leucine-rich repeat [structural motif]
      cd16040
      Location:798 → 977
      SPRY_PRY_SNTX; Stonustoxin subunit alpha or SNTX subunit alpha
      pfam05729
      Location:175 → 342
      NACHT; NACHT domain
      pfam14484
      Location:96 → 166
      FISNA; Fish-specific NACHT associated domain
      cl26161
      Location:592 → 789
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. XM_021477864.1 → XP_021333539.1  protein NLRC3

      UniProtKB/TrEMBL
      A0A8M2B723, F1R020
      Conserved Domains (5) summary
      sd00031
      Location:696 → 724
      LRR_1; leucine-rich repeat [structural motif]
      cd16040
      Location:798 → 977
      SPRY_PRY_SNTX; Stonustoxin subunit alpha or SNTX subunit alpha
      pfam05729
      Location:175 → 342
      NACHT; NACHT domain
      pfam14484
      Location:96 → 166
      FISNA; Fish-specific NACHT associated domain
      cl26161
      Location:592 → 789
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein
    Heading Accession and Version

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