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    mc5ra melanocortin 5a receptor [ Danio rerio (zebrafish) ]

    Gene ID: 286834, updated on 27-Mar-2024

    Summary

    Official Symbol
    mc5raprovided by ZNC
    Official Full Name
    melanocortin 5a receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021223-3
    See related
    Ensembl:ENSDARG00000031348 AllianceGenome:ZFIN:ZDB-GENE-021223-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mc5ar; mc5rb; zMC5a
    Summary
    Enables protein heterodimerization activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human MC5R (melanocortin 5 receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See mc5ra in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (12762846..12804424)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (12843274..12884684)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member Aa Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene collagen triple helix repeat containing 1a Neighboring gene solute carrier family 25 member 32a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables melanocortin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables melanocortin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    melanocortin 5a receptor; melanocortin receptor 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173279.1NP_775386.1  melanocortin 5a receptor

      See identical proteins and their annotated locations for NP_775386.1

      Status: PROVISIONAL

      Source sequence(s)
      AY078990
      UniProtKB/TrEMBL
      B3DHK4, Q8JGW2
      Related
      ENSDARP00000040072.4, ENSDART00000040073.5
      Conserved Domains (2) summary
      pfam00001
      Location:46288
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:36160
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      12762846..12804424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159581.4XP_005159638.1  melanocortin receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005159638.1

      UniProtKB/TrEMBL
      A0A8M2B692, A3KGQ1
      Related
      ENSDARP00000120348.2, ENSDART00000139909.3
      Conserved Domains (2) summary
      pfam00001
      Location:58300
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48172
      7tm_4; Olfactory receptor