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    dnm2b dynamin 2b [ Danio rerio (zebrafish) ]

    Gene ID: 406525, updated on 27-Mar-2024

    Summary

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    Official Symbol
    dnm2bprovided by ZNC
    Official Full Name
    dynamin 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2371
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040426-2371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dnm2; dnm2l; zgc:77233
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including glomerular filtration; glomerular visceral epithelial cell development; and muscle cell development. Predicted to be located in cytoplasm and microtubule. Is expressed in brain; heart; liver; muscle; and spinal cord. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See dnm2b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (58853360..58880378, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (58135604..58183375, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003334086.1 (263..1248, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor ligand superfamily member 14-like Neighboring gene transmembrane p24 trafficking protein 1b Neighboring gene microfibril-associated glycoprotein 4-like Neighboring gene microfibril-associated glycoprotein 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Two dynamin-2 genes are required for normal zebrafish development. Gibbs EM, et al. PLoS One, 2013. PMID 23418470, Free PMC Article
    2. Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome. Koutsopoulos OS, et al. Eur J Hum Genet, 2013 Jun. PMID 23092955, Free PMC Article
    3. Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly. Lepage SE, et al. Dev Biol, 2014 Jan 1. PMID 24161849
    4. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Schiffer M, et al. Nat Med, 2015 Jun. PMID 25962121, Free PMC Article
    5. Evolution of the miR199-214 cluster and vertebrate skeletal development. Desvignes T, et al. RNA Biol, 2014. PMID 24643020, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynamin-2
    Names
    dynamin2-like
    NP_998407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213242.1 → NP_998407.1  dynamin-2

      See identical proteins and their annotated locations for NP_998407.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065325
      UniProtKB/TrEMBL
      Q6P122
      Conserved Domains (6) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79 → 732
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514 → 624
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:645 → 733
      GED; Dynamin GTPase effector domain
      cl23807
      Location:745 → 800
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      58853360..58880378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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