Vasp vasodilator-stimulated phosphoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vaspprovided by RGD
Official Full Name: vasodilator-stimulated phosphoproteinprovided by RGD
Primary source: RGD:1311542
See related: Ensembl:ENSRNOG00000016367 AllianceGenome:RGD:1311542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity and profilin binding activity. Predicted to be involved in actin cytoskeleton organization; nervous system development; and positive regulation of actin filament polymerization. Predicted to be located in several cellular components, including filopodium; focal adhesion; and lamellipodium. Orthologous to human VASP (vasodilator stimulated phosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 297.5), Lung (RPKM 200.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88038026..88053783, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78910009..78925791, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80170608..80185882, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study showed that Arp2/3 and VASP, but not formins, are needed in lateral amygdala for long-term, but not short-term, fear memory formation. Results suggest a mechanism whereby actin cytoskeleton remodeling leads to changes in neuronal morphogenesis needed for memory consolidation.
Title: Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
findings have uncovered a PKG/VASP signaling pathway in Vascular Smooth Muscle Cells as a key molecular mechanism underlying T3-induced vascular relaxation.
Title: Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells.
Co-expression of VASP increased the ability of Mena and EVL to form mixed oligomers.
Title: Selectivity in subunit composition of Ena/VASP tetramers.
These results suggest that diminished VASP expression and/or Ser157 phosphorylation mediates endothelial changes associated with hypertension and exercise may normalize these changes.
Title: Hypertension alters phosphorylation of VASP in brain endothelial cells.
In the presence of acute kidney injury in severe, acute pancreatitis, the renal expression of MMP-9 and VASP is related to damage of endothelial cells in capillaries, which reached a maximum at 24 h and declined afterwards.
Title: Matrix Metalloproteinase 9 and Vasodilator-Stimulated Phosphoprotein Related to Acute Kidney Injury in Severe Acute Pancreatitis Rats.
Studied that Dai Huang Fu Zi Tang markedly elevated the blood flow of small intestine, protected the intestinal barrier function by up-regulating the expression of ZO-1 protein and down-regulating expression of p-VASP.
Title: Dai Huang Fu Zi Tang could ameliorate intestinal injury in a rat model of hemorrhagic shock by regulating intestinal blood flow and intestinal expression of p-VASP and ZO-1.
But reduces VASP phosphorylation.
Title: A short-term incubation with high glucose impairs VASP phosphorylation at serine 239 in response to the nitric oxide/cGMP pathway in vascular smooth muscle cells: role of oxidative stress.
Our findings show that VASP phosphorylation is affected by hypoxia and VEGFR2 inhibition suggesting a role for VASP in BBB permeability.
Title: Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers.
Hepatic up-regulation of Vasp in rats with secondary biliary cirrhosis by expression in the peritubular vascular plexus is reported.
Title: Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus.
Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.
Title: Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA956278 (e-PCR)
- UniSTS:247411

BF405517 (e-PCR)
- UniSTS:247927

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: vasodilator-stimulated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108475.2 → NP_001101945.2 vasodilator-stimulated phosphoprotein

See identical proteins and their annotated locations for NP_001101945.2

Status: PROVISIONAL

Source sequence(s)

BC168841

UniProtKB/TrEMBL

A0A8I6A7U4, B5DEX4

Related

ENSRNOP00000088421.1, ENSRNOT00000096980.1

Conserved Domains (2) summary

cd01207
Location:6 → 114

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:340 → 372

VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88038026..88053783 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081742.2 → XP_038937670.1 vasodilator-stimulated phosphoprotein isoform X5

UniProtKB/TrEMBL

A6J8L5, A6J8L6

Conserved Domains (3) summary

cd01207
Location:6 → 114

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:340 → 373

VASP_tetra; VASP tetramerisation domain

cd22185
Location:216 → 242

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_039081733.2 → XP_038937661.1 vasodilator-stimulated phosphoprotein isoform X2

UniProtKB/TrEMBL

A6J8L6, F7EWC1

Related

ENSRNOP00000022214.8

Conserved Domains (3) summary

cd01207
Location:6 → 114

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:341 → 374

VASP_tetra; VASP tetramerisation domain

cd22185
Location:216 → 242

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_039081746.2 → XP_038937674.1 vasodilator-stimulated phosphoprotein isoform X6

UniProtKB/TrEMBL

A0A8I6A7U4

Conserved Domains (3) summary

cd01207
Location:7 → 115

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:340 → 373

VASP_tetra; VASP tetramerisation domain

cd22185
Location:217 → 240

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_039081741.2 → XP_038937669.1 vasodilator-stimulated phosphoprotein isoform X4

UniProtKB/TrEMBL

A0A8I6A7U4

Conserved Domains (3) summary

cd01207
Location:7 → 115

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:341 → 374

VASP_tetra; VASP tetramerisation domain

cd22185
Location:217 → 240

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_039081738.2 → XP_038937666.1 vasodilator-stimulated phosphoprotein isoform X3

UniProtKB/TrEMBL

A6J8L6

Conserved Domains (3) summary

cd01207
Location:7 → 115

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:341 → 374

VASP_tetra; VASP tetramerisation domain

cd22185
Location:217 → 243

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
XM_039081727.2 → XP_038937655.1 vasodilator-stimulated phosphoprotein isoform X1

UniProtKB/TrEMBL

A6J8L6

Conserved Domains (3) summary

cd01207
Location:7 → 115

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:342 → 375

VASP_tetra; VASP tetramerisation domain

cd22185
Location:217 → 243

WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins