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    SGTB small glutamine rich tetratricopeptide repeat co-chaperone beta [ Homo sapiens (human) ]

    Gene ID: 54557, updated on 7-Apr-2024

    Summary

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    Official Symbol
    SGTBprovided by HGNC
    Official Full Name
    small glutamine rich tetratricopeptide repeat co-chaperone betaprovided by HGNC
    Primary source
    HGNC:HGNC:23567
    See related
    Ensembl:ENSG00000197860 MIM:620526; AllianceGenome:HGNC:23567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGT2
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in positive regulation of chaperone-mediated protein folding; posttranslational protein targeting to endoplasmic reticulum membrane; and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 18.1), appendix (RPKM 4.3) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SGTB in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65665928..65723013, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66487700..66547014, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64961755..65017936, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22608 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene tripartite motif containing 23 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:64934876-64935323 Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22609 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:65015266-65015462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16056 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65018623-65019444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16059 Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16060 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:65220503-65221127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65221752-65222376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22612 Neighboring gene LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene erbb2 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta. Shi L, et al. FEBS J, 2023 Feb. PMID 36180981
    2. miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB. Tian Q, et al. Future Oncol, 2019 Jun. PMID 30943053
    3. Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide. Cao M, et al. J Mol Histol, 2013 Oct. PMID 23820636
    4. Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines. Heavner GA, et al. Regul Pept, 1990 Feb 4. PMID 2158125
    5. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. Vuong TA, et al. Cell Signal, 2019 Mar. PMID 30639199

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad.
      Title: Dynamic stability of Sgt2 enables selective and privileged client handover in a chaperone triad.
    2. Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta.
      Title: Bioinformatics identification of miR-514b-5p promotes NSCLC progression and induces PI3K/AKT and p38 pathways by targeting small glutamine-rich tetratricopeptide repeat-containing protein beta.
    3. miR-365b promoted hepatocellular carcinoma (HCC) cell motility and spreading. Furthermore, SGTB was found to be a downstream target of miR-365b, and knockdown of the SGTB gene could mimic the effect of miR-365b in hastening HCC cell migration and invasion. These results imply that miR-365b plays a tumor-promoting role in HCC by suppressing SGTB expression.
      Title: miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating SGTB.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39002

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein beta
    Names
    beta-SGT
    small glutamine rich protein with tetratricopeptide repeats 2
    small glutamine rich tetratricopeptide repeat containing beta
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019072.3 → NP_061945.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

      See identical proteins and their annotated locations for NP_061945.1

      Status: VALIDATED

      Source sequence(s)
      AC008560, AL713334, BC012044
      Consensus CDS
      CCDS3988.1
      UniProtKB/Swiss-Prot
      Q96EQ0
      Related
      ENSP00000370395.4, ENST00000381007.9
      Conserved Domains (3) summary
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      65665928..65723013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248548.4 → XP_005248605.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

      See identical proteins and their annotated locations for XP_005248605.1

      UniProtKB/Swiss-Prot
      Q96EQ0
      Conserved Domains (3) summary
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    2. XM_047417334.1 → XP_047273290.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      66487700..66547014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352854.1 → XP_054208829.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

      UniProtKB/Swiss-Prot
      Q96EQ0

    2. XM_054352855.1 → XP_054208830.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96EQ0.1 GenPept UniProtKB/Swiss-Prot:Q96EQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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