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    SULF2 sulfatase 2 [ Homo sapiens (human) ]

    Gene ID: 55959, updated on 11-Apr-2024

    Summary

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    Official Symbol
    SULF2provided by HGNC
    Official Full Name
    sulfatase 2provided by HGNC
    Primary source
    HGNC:HGNC:20392
    See related
    Ensembl:ENSG00000196562 MIM:610013; AllianceGenome:HGNC:20392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSULF-2
    Summary
    Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 36.9), endometrium (RPKM 36.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SULF2 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (47657406..47786627, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (49395801..49525734, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (46286150..46415371, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr20.2047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12980 Neighboring gene RNA, U6 small nuclear 563, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46152763-46153530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46158187-46158687 Neighboring gene nuclear receptor coactivator 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:46190110-46190292 Neighboring gene MPRA-validated peak4234 silencer Neighboring gene ribosomal protein S3A pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:46276897-46277614 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46277615-46278332 Neighboring gene nuclear receptor coactivator 3 repeat instability region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46293563-46294548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46294549-46295532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46303203-46304168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46307531-46308031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46316712-46317262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46317263-46317814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46326206-46326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339340-46339840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46339841-46340341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381087-46381588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46381589-46382088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386138-46386895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46386896-46387654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46387655-46388411 Neighboring gene NANOG hESC enhancer GRCh37_chr20:46390145-46390683 Neighboring gene Sharpr-MPRA regulatory region 8498 Neighboring gene uncharacterized LOC124904922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18007 Neighboring gene uncharacterized LOC124904920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18008 Neighboring gene uncharacterized LOC124904921 Neighboring gene uncharacterized LOC107985401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46428971-46429590 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46432238-46433192 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:46433193-46434147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46437768-46438349 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:46438350-46438930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:46454838-46455538 Neighboring gene RNA, U7 small nuclear 173 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts. Siegel RJ, et al. Cell Mol Immunol, 2022 Oct. PMID 36068294, Free PMC Article
    2. Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity. El Masri R, et al. Cell Rep, 2022 Mar 15. PMID 35294879
    3. Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer. Yang YW, et al. Exp Lung Res, 2021 May-Aug. PMID 33908819
    4. Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis. Luo X, et al. Hepatology, 2021 Sep. PMID 33735525, Free PMC Article
    5. Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate. Seffouh A, et al. Cell Mol Life Sci, 2019 May. PMID 30788513, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-alpha-induced inflammatory activation of synovial fibroblasts.
      Title: Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts.
    2. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
      Title: SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.
    3. Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.
      Title: Extracellular sulfatases as potential blood-based biomarkers for early detection of lung cancer.
    4. Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis.
      Title: Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2-Platelet-Derived Growth Factor Receptor Beta-Yes-Associated Protein Signaling Axis.
    5. miR-527 targeting SULF2 down-regulates SULF2 expression, concurrently, suppresses NSCLC epithelial-mesenchymal transition and invasion via inhibiting TGF-beta/SMAD signaling pathway in non-small-cell lung cancer
      Title: MicroRNA-527 inhibits TGF-β/SMAD induced epithelial-mesenchymal transition via downregulating SULF2 expression in non-small-cell lung cancer.
    6. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
      Title: TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
    7. Loss of SULF2 expression is associated with corticospinal tract defect.
      Title: Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.
    8. SULF2 plays a key role in sorafenib susceptibility.
      Title: Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer.
    9. High SULF2 expression is associated with glioma.
      Title: Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.
    10. The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors.
      Title: Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variation in GPC5 is associated with acquired nephrotic syndrome.
    EBI GWAS Catalog
    Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44488, FLJ90554, KIAA1247, MGC126411, DKFZp313E091

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine-6-sulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylglucosamine-6-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylsulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cartilage development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chondrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in embryonic skeletal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in esophagus smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glomerular basement membrane development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in innervation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelin production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    extracellular sulfatase Sulf-2
    Names
    N-acetylglucosamine-6-sulfatase
    arylsulfatase
    NP_001155313.1
    NP_001373977.1
    NP_001373978.1
    NP_001373979.1
    NP_001373980.1
    NP_001373981.1
    NP_001373982.1
    NP_001373983.1
    NP_001373984.1
    NP_061325.1
    NP_940998.2
    XP_047296251.1
    XP_047296252.1
    XP_047296253.1
    XP_047296254.1
    XP_047296255.1
    XP_047296256.1
    XP_047296257.1
    XP_054179677.1
    XP_054179678.1
    XP_054179679.1
    XP_054179680.1
    XP_054179681.1
    XP_054179682.1
    XP_054179683.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161841.2 → NP_001155313.1  extracellular sulfatase Sulf-2 isoform a precursor

      See identical proteins and their annotated locations for NP_001155313.1

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Consensus CDS
      CCDS13408.1
      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
      Related
      ENSP00000418290.1, ENST00000484875.5
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 661
      DUF3740; Sulfatase protein
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_001387048.1 → NP_001373977.1  extracellular sulfatase Sulf-2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Consensus CDS
      CCDS13408.1
      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
      Related
      ENSP00000508753.1, ENST00000688720.1
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 661
      DUF3740; Sulfatase protein
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    3. NM_001387049.1 → NP_001373978.1  extracellular sulfatase Sulf-2 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Consensus CDS
      CCDS13408.1
      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 661
      DUF3740; Sulfatase protein
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    4. NM_001387050.1 → NP_001373979.1  extracellular sulfatase Sulf-2 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 662
      DUF3740; Sulfatase protein
      cl23718
      Location:750 → 799
      ALP_like; alkaline phosphatases and sulfatases

    5. NM_001387051.1 → NP_001373980.1  extracellular sulfatase Sulf-2 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 661
      DUF3740; Sulfatase protein
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    6. NM_001387052.1 → NP_001373981.1  extracellular sulfatase Sulf-2 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 662
      DUF3740; Sulfatase protein
      cl23718
      Location:750 → 799
      ALP_like; alkaline phosphatases and sulfatases

    7. NM_001387053.1 → NP_001373982.1  extracellular sulfatase Sulf-2 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 662
      DUF3740; Sulfatase protein
      cl23718
      Location:750 → 799
      ALP_like; alkaline phosphatases and sulfatases

    8. NM_001387054.1 → NP_001373983.1  extracellular sulfatase Sulf-2 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 662
      DUF3740; Sulfatase protein
      cl23718
      Location:750 → 799
      ALP_like; alkaline phosphatases and sulfatases

    9. NM_001387055.1 → NP_001373984.1  extracellular sulfatase Sulf-2 isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 662
      DUF3740; Sulfatase protein
      cl23718
      Location:750 → 799
      ALP_like; alkaline phosphatases and sulfatases

    10. NM_018837.4 → NP_061325.1  extracellular sulfatase Sulf-2 isoform a precursor

      See identical proteins and their annotated locations for NP_061325.1

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Consensus CDS
      CCDS13408.1
      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3
      Related
      ENSP00000353007.4, ENST00000359930.8
      Conserved Domains (3) summary
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:529 → 661
      DUF3740; Sulfatase protein
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    11. NM_198596.3 → NP_940998.2  extracellular sulfatase Sulf-2 isoform b precursor

      See identical proteins and their annotated locations for NP_940998.2

      Status: VALIDATED

      Source sequence(s)
      AL034418, AL121777, AL354813
      Consensus CDS
      CCDS13409.2
      UniProtKB/Swiss-Prot
      Q8IWU5
      Related
      ENSP00000418442.1, ENST00000467815.5
      Conserved Domains (4) summary
      COG3119
      Location:43 → 395
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      pfam12548
      Location:535 → 661
      DUF3740; Sulfatase protein
      cd16147
      Location:43 → 385
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      cl23718
      Location:749 → 798
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      47657406..47786627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440296.1 → XP_047296252.1  extracellular sulfatase Sulf-2 isoform X2

      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

    2. XM_047440295.1 → XP_047296251.1  extracellular sulfatase Sulf-2 isoform X1

    3. XM_047440297.1 → XP_047296253.1  extracellular sulfatase Sulf-2 isoform X3

    4. XM_047440300.1 → XP_047296256.1  extracellular sulfatase Sulf-2 isoform X4

    5. XM_047440298.1 → XP_047296254.1  extracellular sulfatase Sulf-2 isoform X3

    6. XM_047440299.1 → XP_047296255.1  extracellular sulfatase Sulf-2 isoform X4

    7. XM_047440301.1 → XP_047296257.1  extracellular sulfatase Sulf-2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      49395801..49525734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323703.1 → XP_054179678.1  extracellular sulfatase Sulf-2 isoform X6

      UniProtKB/Swiss-Prot
      E1P5U6, Q5JYE1, Q6UX86, Q8IWU5, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3

    2. XM_054323702.1 → XP_054179677.1  extracellular sulfatase Sulf-2 isoform X5

    3. XM_054323704.1 → XP_054179679.1  extracellular sulfatase Sulf-2 isoform X3

    4. XM_054323706.1 → XP_054179681.1  extracellular sulfatase Sulf-2 isoform X4

    5. XM_054323705.1 → XP_054179680.1  extracellular sulfatase Sulf-2 isoform X3

    6. XM_054323707.1 → XP_054179682.1  extracellular sulfatase Sulf-2 isoform X4

    7. XM_054323708.1 → XP_054179683.1  extracellular sulfatase Sulf-2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWU5.1 GenPept UniProtKB/Swiss-Prot:Q8IWU5

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