Wdr76 WD repeat domain 76 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr76provided by MGI
Official Full Name: WD repeat domain 76provided by MGI
Primary source: MGI:MGI:1926186
See related: Ensembl:ENSMUSG00000027242 AllianceGenome:MGI:1926186
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6030457D09; 5830411K18Rik
Summary: Predicted to enable DNA binding activity and enzyme binding activity. Predicted to be involved in cellular response to DNA damage stimulus and regulation of DNA damage checkpoint. Predicted to be located in heterochromatin and site of DNA damage. Predicted to be active in nucleus. Orthologous to human WDR76 (WD repeat domain 76). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 5.6), CNS E11.5 (RPKM 5.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.41 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (121337204..121375341)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (121506723..121544860)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR76 mediates obesity and hepatic steatosis via HRas destabilization.
Title: WDR76 mediates obesity and hepatic steatosis via HRas destabilization.
Study identifies WD40-repeat protein 76 (WDR76) as one of the HRAS binding proteins using proteomic analyses of hepatocellular carcinomas tissue form human patients and mouse diethylnitrosamine-induced liver carcinogenesis model and demonstrates that WDR76 functions as a tumor suppressor via RAS degradation.
Title: WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage checkpoint	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WD repeat-containing protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290986.1 → NP_001277915.1 WD repeat-containing protein 76 isoform a

See identical proteins and their annotated locations for NP_001277915.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK031592, BC094676, BY720216

Consensus CDS

CCDS38218.1

UniProtKB/Swiss-Prot

A6PWY4

Related

ENSMUSP00000106232.3, ENSMUST00000110602.9

Conserved Domains (3) summary

COG2319
Location:214 → 484

WD40; WD40 repeat [General function prediction only]

sd00039
Location:218 → 258

7WD40; WD40 repeat [structural motif]

cl02567
Location:214 → 423

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001290987.1 → NP_001277916.1 WD repeat-containing protein 76 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AK031592, BC094676, BY720216

UniProtKB/Swiss-Prot

A6PWY4

Conserved Domains (3) summary

COG2319
Location:60 → 330

WD40; WD40 repeat [General function prediction only]

sd00039
Location:64 → 104

7WD40; WD40 repeat [structural motif]

cl02567
Location:60 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001369185.1 → NP_001356114.1 WD repeat-containing protein 76 isoform c

Status: VALIDATED

Description

Transcript Variant: This isoform encodes the longest isoform (c).

Source sequence(s)

AL928678

Consensus CDS

CCDS89546.1

UniProtKB/Swiss-Prot

A2ASQ8, A4FUV0, A6PWY4, Q504Z3, Q9CTV4

Related

ENSMUSP00000106234.2, ENSMUST00000110603.2

Conserved Domains (2) summary

sd00039
Location:316 → 356

7WD40; WD40 repeat [structural motif]

cl29593
Location:312 → 521

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_030234.2 → NP_084510.2 WD repeat-containing protein 76 isoform a

See identical proteins and their annotated locations for NP_084510.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AK031592, AK162181, BC094676, BY019145

Consensus CDS

CCDS38218.1

UniProtKB/Swiss-Prot

A6PWY4

Related

ENSMUSP00000028676.6, ENSMUST00000028676.12

Conserved Domains (3) summary

COG2319
Location:214 → 484

WD40; WD40 repeat [General function prediction only]

sd00039
Location:218 → 258

7WD40; WD40 repeat [structural motif]

cl02567
Location:214 → 423

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...