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    Gcc2 GRIP and coiled-coil domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70297, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gcc2provided by MGI
    Official Full Name
    GRIP and coiled-coil domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917547
    See related
    Ensembl:ENSMUSG00000038039 AllianceGenome:MGI:1917547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0336; 0610043A03Rik; 2210420P05Rik; 2600014C01Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; protein localization to organelle; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within protein transport. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in Golgi apparatus. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gcc2 in Genome Data Viewer
    Location:
    10 B4; 10 29.3 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58091240..58141421)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (58255408..58305599)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2935 Neighboring gene double homeobox family member 4 Neighboring gene double homeobox family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E575 Neighboring gene STARR-seq mESC enhancer starr_26754 Neighboring gene LIM and senescent cell antigen-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E6854 Neighboring gene predicted gene, 23058 Neighboring gene STARR-positive B cell enhancer ABC_E2936 Neighboring gene RAN binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. Clapp J, et al. Am J Hum Genet, 2007 Aug. PMID 17668377, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    3. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in late endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule anchoring ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in recycling endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRIP and coiled-coil domain-containing protein 2
    Names
    185 kDa Golgi coiled-coil protein
    GCC185

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027375.3 → NP_081651.2  GRIP and coiled-coil domain-containing protein 2

      See identical proteins and their annotated locations for NP_081651.2

      Status: VALIDATED

      Source sequence(s)
      AC170751
      Consensus CDS
      CCDS23859.1
      UniProtKB/Swiss-Prot
      B2RSU7, Q8BR44, Q8CHG3, Q8R2Q5, Q9CT45
      UniProtKB/TrEMBL
      E9PWI6
      Related
      ENSMUSP00000054033.8, ENSMUST00000057659.14
      Conserved Domains (4) summary
      TIGR02168
      Location:624 → 1386
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01465
      Location:1610 → 1652
      GRIP; GRIP domain
      pfam07851
      Location:104 → 203
      TMPIT; TMPIT-like protein
      pfam16704
      Location:1544 → 1608
      Rab_bind; Rab binding domain

    RNA

    1. NR_176435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC170751

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      58091240..58141421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155993.1 → XP_036011886.1  GRIP and coiled-coil domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      E0CYI9
      Related
      ENSMUSP00000124152.2, ENSMUST00000162860.8
      Conserved Domains (4) summary
      COG1196
      Location:227 → 1044
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:654 → 1370
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam16704
      Location:1444 → 1508
      Rab_bind; Rab binding domain
      pfam01465
      Location:1510 → 1552
      GRIP; GRIP domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHG3.3 GenPept UniProtKB/Swiss-Prot:Q8CHG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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