Bgn biglycan [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bgnprovided by RGD
Official Full Name: biglycanprovided by RGD
Primary source: RGD:2207
See related: Ensembl:ENSRNOG00000055962 AllianceGenome:RGD:2207
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BSPG1
Summary: Predicted to enable extracellular matrix binding activity and glycosaminoglycan binding activity. Involved in blood vessel remodeling. Predicted to be located in several cellular components, including cell surface; sarcolemma; and transport vesicle. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Meester-Loeys syndrome and X-linked spondyloepimetaphyseal dysplasia. Orthologous to human BGN (biglycan). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 537.1), Spleen (RPKM 380.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (156348633..156360797)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (151197296..151209458)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (157319042..157331204, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BGN overexpression positively regulates proliferation and osteogenic potential of mesenchymal stem cells.
Title: Lentiviral delivery of biglycan promotes proliferation and increases osteogenic potential of bone marrow-derived mesenchymal stem cells in vitro.
In cardiac fibroblasts, biglycan is induced by a variety of stimuli including serum, thrombin and growth factors such as PDGF-BB and TGFbeta1.
Title: Transcriptional and posttranscriptional regulators of biglycan in cardiac fibroblasts.
Increased expression of biglycan mRNA in pressure-overloaded rat heart.
Title: Increased expression of biglycan mRNA in pressure-overloaded rat heart.
biglycan has a role in signaling; nitric oxide modulates the course of renal glomerular disease through regulation of biglycan expression
Title: Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bgn (e-PCR), detects polymorphism
- UniSTS:531304

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in articular cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within articular cartilage development	ISO Inferred from Sequence Orthology more info
involved_in blood vessel remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: biglycan

Names: PG-S1; Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor); bone/cartilage proteclycan 1; bone/cartilage proteoglycan I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017087.1 → NP_058783.1 biglycan precursor

See identical proteins and their annotated locations for NP_058783.1

Status: PROVISIONAL

Source sequence(s)

U17834

UniProtKB/Swiss-Prot

P47853

UniProtKB/TrEMBL

A0A8L2R772, A6KRY1

Related

ENSRNOP00000078269.1, ENSRNOT00000119907.1

Conserved Domains (2) summary

PRK15370
Location:65 → 298

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

sd00033
Location:72 → 92

LRR_RI; leucine-rich repeat [structural motif]