scd stearoyl-CoA desaturase (delta-9-desaturase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scdprovided by ZNC
Official Full Name: stearoyl-CoA desaturase (delta-9-desaturase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-031106-3
See related: Ensembl:ENSDARG00000033662 AllianceGenome:ZFIN:ZDB-GENE-031106-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: SCD1
Summary: Predicted to enable iron ion binding activity; palmitoyl-CoA 9-desaturase activity; and stearoyl-CoA 9-desaturase activity. Predicted to be involved in monounsaturated fatty acid biosynthetic process; response to fatty acid; and unsaturated fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brain; female organism; heart; liver; and muscle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (48390713..48406198)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (48407391..48422876)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

scd knockout activates beta-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish.
Title: scd knockout activates β-oxidation of fatty acids via accumulating stearic acid (18:0) and induces anorexia in zebrafish.
Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.
Title: Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy.
whole-mount in situ hybridization and real-time quantitative RT-PCR to identify expression of the zebrafish SCD gene at five different stages of development
Title: cDNA nucleotide sequence coding for stearoyl-CoA desaturase and its expression in the zebrafish (Danio rerio) embryo.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables iron ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fat pad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monounsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within swimming behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-CoA desaturase

NP_942110.2

EC 1.14.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198815.2 → NP_942110.2 acyl-CoA desaturase

Status: VALIDATED

Source sequence(s)

FP102054

UniProtKB/TrEMBL

A0A8M1P985, F1QG70

Related

ENSDARP00000124185.1, ENSDART00000149351.2

Conserved Domains (2) summary

cd03505
Location:64 → 304

Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

pfam00487
Location:68 → 273

FA_desaturase; Fatty acid desaturase