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    arhgap21b Rho GTPase activating protein 21b [ Danio rerio (zebrafish) ]

    Gene ID: 326745, updated on 25-Apr-2024

    Summary

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    Official Symbol
    arhgap21bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 21bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4944
    See related
    Ensembl:ENSDARG00000075673 AllianceGenome:ZFIN:ZDB-GENE-030131-4944
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe14a09; wu:fe14a09; si:ch211-175p12.1
    Summary
    Predicted to enable GTPase activator activity and phospholipid binding activity. Predicted to act upstream of or within signal transduction. Orthologous to human ARHGAP21 (Rho GTPase activating protein 21). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See arhgap21b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (12302637..12406641)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (12619528..12723855)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 158b Neighboring gene phosphoribosyl transferase domain containing 1b Neighboring gene dipeptidyl-peptidase 6b Neighboring gene uncharacterized LOC110437990

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho GTPase activating protein 21; rho GTPase-activating protein 21
    Names
    spork

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      12302637..12406641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298105.3 → XP_009296380.1  rho GTPase-activating protein 21 isoform X4

      See identical proteins and their annotated locations for XP_009296380.1

      UniProtKB/TrEMBL
      A0A8M3AZS7
      Conserved Domains (4) summary
      cd00992
      Location:50 → 156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1031 → 1227
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:817 → 931
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:817 → 926
      PH; PH domain

    2. XM_009298106.3 → XP_009296381.1  rho GTPase-activating protein 21 isoform X4

      See identical proteins and their annotated locations for XP_009296381.1

      UniProtKB/TrEMBL
      A0A8M3AZS7
      Conserved Domains (4) summary
      cd00992
      Location:50 → 156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1031 → 1227
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:817 → 931
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:817 → 926
      PH; PH domain

    3. XM_001918933.6 → XP_001918968.3  rho GTPase-activating protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8M1QQH1, F1QST2
      Related
      ENSDARP00000085731.4, ENSDART00000091298.7
      Conserved Domains (4) summary
      cd00992
      Location:50 → 156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1031 → 1227
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:817 → 931
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:817 → 926
      PH; PH domain

    4. XM_009298094.3 → XP_009296369.1  rho GTPase-activating protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A8M3APT5
      Conserved Domains (4) summary
      cd00992
      Location:50 → 156
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:1031 → 1227
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:817 → 931
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:817 → 926
      PH; PH domain

    5. XM_009298096.3 → XP_009296371.1  rho GTPase-activating protein 21 isoform X3

      See identical proteins and their annotated locations for XP_009296371.1

      UniProtKB/TrEMBL
      A0A8M3AWP2
      Conserved Domains (3) summary
      cd04395
      Location:827 → 1023
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:613 → 727
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:613 → 722
      PH; PH domain

    6. XM_005163293.4 → XP_005163350.1  rho GTPase-activating protein 21 isoform X3

      See identical proteins and their annotated locations for XP_005163350.1

      UniProtKB/TrEMBL
      A0A8M3AWP2
      Conserved Domains (3) summary
      cd04395
      Location:827 → 1023
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:613 → 727
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:613 → 722
      PH; PH domain

    RNA

    1. XR_002455799.1 RNA Sequence

    2. XR_002455798.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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