U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lin7c lin-7 homolog C (C. elegans) [ Danio rerio (zebrafish) ]

    Gene ID: 447934, updated on 27-Mar-2024

    Summary

    Official Symbol
    lin7cprovided by ZNC
    Official Full Name
    lin-7 homolog C (C. elegans)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041011-2
    See related
    Ensembl:ENSDARG00000027322 AllianceGenome:ZFIN:ZDB-GENE-041011-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb75b09; wu:fb75b09; zgc:101881
    Summary
    Enables L27 domain binding activity. Acts upstream of or within maintenance of epithelial cell apical/basal polarity. Predicted to be located in plasma membrane and presynapse. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. Is expressed in several structures, including eye; neural rod; neural tube; neuroepithelial cell; and optic vesicle. Orthologous to human LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See lin7c in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (31902333..31921591, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (31631183..31650441, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cysteinyl-tRNA synthetase 1 Neighboring gene myosin binding protein C3 Neighboring gene uncharacterized LOC103911387 Neighboring gene brain-derived neurotrophic factor Neighboring gene kinesin family member 18A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L27 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L27 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MPP7-DLG1-LIN7 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein lin-7 homolog C
    Names
    neuroepithelial polarity protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004672.2NP_001004672.1  protein lin-7 homolog C

      See identical proteins and their annotated locations for NP_001004672.1

      Status: PROVISIONAL

      Source sequence(s)
      AY584748
      UniProtKB/TrEMBL
      B2GTJ0, Q66IB0
      Related
      ENSDARP00000118823.1, ENSDART00000146720.3
      Conserved Domains (2) summary
      cd00992
      Location:91172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:1466
      L27; L27 domain
    2. NM_001362514.1NP_001349443.1  protein lin-7 homolog C

      Status: VALIDATED

      Source sequence(s)
      AL935207
      UniProtKB/TrEMBL
      B2GTJ0, Q66IB0
      Conserved Domains (2) summary
      cd00992
      Location:91172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:1466
      L27; L27 domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      31902333..31921591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)