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    clec-38 C-type lectin domain-containing protein 38 [ Caenorhabditis elegans ]

    Gene ID: 188900, updated on 15-Oct-2023

    Summary

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    Gene symbol
    clec-38
    Gene description
    C-type lectin domain-containing protein 38
    Primary source
    WormBase:WBGene00012025
    Locus tag
    CELE_T25E12.10
    See related
    AllianceGenome:WB:WBGene00012025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbohydrate binding activity. Involved in several processes, including generation of neurons; presynapse assembly; and regulation of axon guidance. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in PLML; PLMR; head neurons; intestine; and ventral cord neurons. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See clec-38 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (16733821..16735618, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene Uncharacterized protein Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The roles of multiple UNC-40 (DCC) receptor-mediated signals in determining neuronal asymmetry induced by the UNC-6 (netrin) ligand. Xu Z, et al. Genetics, 2009 Nov. PMID 19704011, Free PMC Article
    2. CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans. Kulkarni G, et al. J Neurosci, 2008 Apr 23. PMID 18434533, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLEC-38 plays a role in promoting synapse assembly and refining axon outgrowth activity.
      Title: CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dorsal/ventral axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of motor neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain-containing protein 38
    NP_507233.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16733821..16735618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074832.4 → NP_507233.2  C-type lectin domain-containing protein 38 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507233.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45824
      Conserved Domains (1) summary
      smart00034
      Location:122 → 250
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    Nucleotide Protein
    Heading Accession and Version

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