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    CG14805 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31146, updated on 10-May-2024

    Summary

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    Official Symbol
    CG14805provided by FlyBase
    Primary source
    FLYBASE:FBgn0023514
    Locus tag
    Dmel_CG14805
    See related
    AllianceGenome:FB:FBgn0023514
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14805; EG:63B12.7; i207
    Summary
    Predicted to be involved in rRNA processing and regulation of DNA-dependent DNA replication initiation. Predicted to be part of Rix1 complex and nuclear pre-replicative complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval muscle system; endoderm anlage; germ layer; and presumptive embryonic/larval digestive system. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG14805 in Genome Data Viewer
    Location:
    2B14-2B14; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1877317..1879077)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1771350..1773110)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5 Neighboring gene Vacuolar protein sorting 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase assembly factor 8 Neighboring gene trithorax-related Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene armadillo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article
    2. The Drosophila MSL complex activates the transcription of target genes. Straub T, et al. Genes Dev, 2005 Oct 1. PMID 16204179, Free PMC Article
    3. Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP. Battersby A, et al. J Mol Biol, 2003 Jun 6. PMID 12767830
    4. A Genome-Wide Screen for Dendritically Localized RNAs Identifies Genes Required for Dendrite Morphogenesis. Misra M, et al. G3 (Bethesda), 2016 Aug 9. PMID 27260999, Free PMC Article
    5. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pre-replicative complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of rixosome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14805-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1877317..1879077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130598.3 → NP_569954.1  uncharacterized protein Dmel_CG14805 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX33, Q9W550
      Related
      FBpp0070299
      Conserved Domains (3) summary
      COG2319
      Location:8 → 320
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:86 → 121
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:82 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46087 O46087
    Q8SX33 Q8SX33
    Q9W550 Q9W550

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