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    CG8170 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35908, updated on 10-May-2024

    Summary

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    Official Symbol
    CG8170provided by FlyBase
    Primary source
    FLYBASE:FBgn0033365
    Locus tag
    Dmel_CG8170
    See related
    AllianceGenome:FB:FBgn0033365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cSP54; Dmel\CG8170; SP54
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human HPN (hepsin); PRSS22 (serine protease 22); and TMPRSS5 (transmembrane serine protease 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG8170 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9019032..9031045, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4906537..4918550, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ance-4 Neighboring gene Prophenoloxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development. Rice C, et al. Genetics, 2020 Dec. PMID 33115752, Free PMC Article
    2. Genes regulated by mating, sperm, or seminal proteins in mated female Drosophila melanogaster. McGraw LA, et al. Curr Biol, 2004 Aug 24. PMID 15324670
    3. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
    4. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
    5. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8170-PA
    CG8170-PB
    NP_001036533.1
    NP_610441.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9019032..9031045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136597.4 → NP_610441.2  uncharacterized protein Dmel_CG8170, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610441.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7M7
      Conserved Domains (2) summary
      smart00020
      Location:611 → 845
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:612 → 846
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001043068.2 → NP_001036533.1  uncharacterized protein Dmel_CG8170, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZK6
      Conserved Domains (2) summary
      smart00020
      Location:534 → 768
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:535 → 769
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7M7 A1Z7M7
    Q7JZK6 Q7JZK6

    Gene LinkOut

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