Slc2a3 solute carrier family 2 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Slc2a3provided by RGD
Full Name: solute carrier family 2 member 3provided by RGD
Primary source: RGD:3706
See related: Ensembl:ENSRNOG00000008376 AllianceGenome:RGD:3706
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GLUT3
Summary: Enables several functions, including dehydroascorbic acid transmembrane transporter activity; galactoside binding activity; and monosaccharide binding activity. Involved in several processes, including dehydroascorbic acid transport; glucose import; and response to Thyroglobulin triiodothyronine. Located in caveola and synaptic vesicle membrane. Is active in glutamatergic synapse. Is integral component of synaptic membrane. Biomarker of cataract and hypertension. Orthologous to human SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 617.3), Brain (RPKM 246.8) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157632887..157698034, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (155960944..156026000, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155549991..155626018, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
Title: Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression.
findings show that age alters glucose uptake and GLUT3/4 expression profiles before and after Spinal Cord Injury.
Title: Aging alters glucose uptake in the naïve and injured rodent spinal cord.
Study found no differences in mRNA or protein levels of neuronal monocarboxylate transporters (MCTs). Functional analyses revealed that neuronal MCT2 had high catalytic efficiency in Huntington's disease (HD) cells. Ascorbic acid did not stimulate lactate uptake in HD cells; and was unable to inhibit glucose transport in HD cells because they exhibit decreased expression of the neuronal glucose transporter GLUT3.
Title: Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.
Hippocampal mRNA abundance of GLUT3 decreases with age in males and females
Title: Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner.
results suggest AMPK-regulated ATP production triggers the release of ATP to activate P2Y receptor signaling, which is another candidate that regulates GLUT3 expression under the ischemic condition
Title: Extracellular ATP-prinoceptor signaling and AMP-activated protein kinase regulate astrocytic glucose transporter 3 in an in vitro ischemia.
Expression of GLUT3 in the cerebral cortex was reduced significantly with age.
Title: [Expression of glucose transporter-3 in the cerebral cortex of aging rats].
CoCl(2) can increase mRNA expressions of GLUT1 and GLUT3 and glucose transporter activity of neurons in hypoxic conditions.
Title: [CoCl2-induced enhancement of glucose transport activity in mediating hypoxic tolerance in cultured hippocampal neurons].
The results show that Hk1 and GLUT3 may play a role in the pathophysiology of ketamine-induced behavioral abnormalities.
Title: The expression of genes involved in glucose metabolism is affected by N-methyl-D-aspartate receptor antagonism: a putative link between metabolism and an animal model of psychosis.
Progesterone could increase the tolerance of neurons to hypoxic-ischemia by up-regulating GLUT1 and GLUT3 expression.
Title: [Effect of progesterone on the expression of GLUT in the brain following hypoxic-ischemia in newborn rats].
Data suggest that triiodothyronine (T3) up-regulates Glut1 and Glut3 in osteoblasts; thus, increased glucose uptake induced by T3 may be mediated by these high-affinity glucose transporters.
Title: Triiodothyronine stimulates glucose transport in bone cells.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144424

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144425

UniSTS:144426 (e-PCR)
- UniSTS:144426

Slc2a3 (e-PCR), detects polymorphism
- UniSTS:144426

PMC20520P1 (e-PCR)
- UniSTS:271942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables fructose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables fructose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables galactose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables glucose binding	IEA Inferred from Electronic Annotation more info
enables glucose binding	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables monosaccharide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables xylose binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
NOT involved_in fructose transmembrane transport	ISO Inferred from Sequence Orthology more info
NOT involved_in fructose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in galactose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in galactose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in monosaccharide transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 3

Names: GLUT-3; Solute carrier family 2 A3 (neuron glucose transporter); glucose transporter type 3, brain; solute carrier family 2 (facilitated glucose transporter), member 3; solute carrier family 2, facilitated glucose transporter member 3-like; solute carrier family 2, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412552.1 → NP_001399481.1 solute carrier family 2, facilitated glucose transporter member 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JSJ3

Related

ENSRNOP00000011298.4, ENSRNOT00000011298.7
NM_017102.3 → NP_058798.2 solute carrier family 2, facilitated glucose transporter member 3 isoform 1

See identical proteins and their annotated locations for NP_058798.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q07647, Q62729

UniProtKB/TrEMBL

A0A0G2JT05, A6ILF8

Related

ENSRNOP00000066684.1, ENSRNOT00000071745.2

Conserved Domains (1) summary

cd17431
Location:12 → 456

MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157632887..157698034 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237296.5 → XP_006237358.1 solute carrier family 2, facilitated glucose transporter member 3 isoform X1

See identical proteins and their annotated locations for XP_006237358.1

UniProtKB/TrEMBL

A0A0G2JSJ3, A0A0G2JVB0

Conserved Domains (2) summary

cd06174
Location:16 → 450

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:15 → 467

Sugar_tr; Sugar (and other) transporter
XM_063285612.1 → XP_063141682.1 solute carrier family 2, facilitated glucose transporter member 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JSJ3
XM_063285613.1 → XP_063141683.1 solute carrier family 2, facilitated glucose transporter member 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JSJ3
XM_063285614.1 → XP_063141684.1 solute carrier family 2, facilitated glucose transporter member 3 isoform X1

UniProtKB/TrEMBL

A0A0G2JSJ3