Ttc36 tetratricopeptide repeat domain 36 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttc36provided by RGD
Official Full Name: tetratricopeptide repeat domain 36provided by RGD
Primary source: RGD:1359544
See related: AllianceGenome:RGD:1359544
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including learning or memory; negative regulation of cellular protein metabolic process; and tyrosine metabolic process. Orthologous to human TTC36 (tetratricopeptide repeat domain 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 863.0) and Kidney (RPKM 749.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (54009522..54013129, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (45112737..45116345, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (49106374..49109981, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tyrosine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 36

Names: TPR repeat protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005546.1 → NP_001005546.1 tetratricopeptide repeat protein 36

See identical proteins and their annotated locations for NP_001005546.1

Status: PROVISIONAL

Source sequence(s)

BC082024

UniProtKB/Swiss-Prot

Q66H45

UniProtKB/TrEMBL

A6J415

Conserved Domains (4) summary

sd00006
Location:48 → 76

TPR; TPR repeat [structural motif]

pfam00515
Location:82 → 111

TPR_1; Tetratricopeptide repeat

pfam13414
Location:47 → 112

TPR_11; TPR repeat

pfam13424
Location:79 → 149

TPR_12; Tetratricopeptide repeat