Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lgr4provided by RGD
Official Full Name: leucine-rich repeat-containing G protein-coupled receptor 4provided by RGD
Primary source: RGD:628615
See related: Ensembl:ENSRNOG00000005715 AllianceGenome:RGD:628615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr48
Summary: Predicted to enable Roundabout binding activity; heparin binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including metanephros development; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 363.4), Liver (RPKM 249.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q34

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (116901968..117004584)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (96447385..96550006)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (101051960..101152119)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low levels of cadmium exposure affect bone by inhibiting Lgr4 expression in osteoblasts and osteoclasts.
Title: Low levels of cadmium exposure affect bone by inhibiting Lgr4 expression in osteoblasts and osteoclasts.
The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development.
Title: A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.
These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis.
Title: LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
NOT enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
NOT enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Roundabout binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in metanephric glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tube morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 4

Names: G-protein coupled receptor 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173328.2 → NP_775450.2 leucine-rich repeat-containing G-protein coupled receptor 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

G3V6R1, Q9Z2H4

UniProtKB/TrEMBL

A0A8I6AJN3

Related

ENSRNOP00000007681.3, ENSRNOT00000007681.5

Conserved Domains (6) summary

smart00013
Location:29 → 61

LRRNT; Leucine rich repeat N-terminal domain

COG4886
Location:62 → 301

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:321 → 344

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:59 → 82

LRR_RI; leucine-rich repeat [structural motif]

cd15361
Location:539 → 812

7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13855
Location:345 → 401

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

116901968..117004584

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104411.2 → XP_038960339.1 leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1

Conserved Domains (4) summary

sd00033
Location:4 → 23

LRR_RI; leucine-rich repeat [structural motif]

cd15361
Location:480 → 753

7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

NF033189
Location:46 → 404

internalin_A; class 1 internalin InlA

pfam13855
Location:4 → 58

LRR_8; Leucine rich repeat