Y57G11C.3 Putative 6-phosphogluconolactonase [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: Y57G11C.3
Gene description: Putative 6-phosphogluconolactonase
Locus tag: CELE_Y57G11C.3
See related: AllianceGenome:WB:WBGene00013301
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in nucleus. Is expressed in germ cell. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Y57G11C.3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 2

Sequence:: Chromosome: IV; NC_003282.8 (14768201..14769063)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y57G11C.3 (e-PCR)
- UniSTS:308193

Y57G11C.4 (e-PCR)
- UniSTS:308194

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 6-phosphogluconolactonase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in sarcomere	HDA more info	PubMed
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: Putative 6-phosphogluconolactonase

NP_001366933.1

Confirmed by transcript evidence

NP_001367136.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14768201..14769063

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380534.1 → NP_001366933.1 Putative 6-phosphogluconolactonase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O18229, Q2EEL9

Conserved Domains (1) summary

cd01400
Location:24 → 245

6PGL; 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the ...
NM_001380535.1 → NP_001367136.1 Putative 6-phosphogluconolactonase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd01400
Location:12 → 233

6PGL; 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the ...