Tomm34 translocase of outer mitochondrial membrane 34 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tomm34provided by RGD
Official Full Name: translocase of outer mitochondrial membrane 34provided by RGD
Primary source: RGD:1309029
See related: Ensembl:ENSRNOG00000029799 AllianceGenome:RGD:1309029
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human TOMM34 (translocase of outer mitochondrial membrane 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 142.4), Thymus (RPKM 99.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173148737..173165689, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152729345..152746295, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160448294..160465143, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134131 (e-PCR)
- UniSTS:217413

RH127744 (e-PCR)
- UniSTS:211054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM34

Names: translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044244.2 → NP_001037709.1 mitochondrial import receptor subunit TOM34

See identical proteins and their annotated locations for NP_001037709.1

Status: PROVISIONAL

Source sequence(s)

BC105768

UniProtKB/Swiss-Prot

Q3KRD5

UniProtKB/TrEMBL

A0A8L2QQ52, A6JX57

Conserved Domains (2) summary

TIGR00990
Location:11 → 294

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:193 → 221

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

173148737..173165689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283870.1 → XP_063139940.1 mitochondrial import receptor subunit TOM34 isoform X2
XM_006235585.5 → XP_006235647.1 mitochondrial import receptor subunit TOM34 isoform X1

See identical proteins and their annotated locations for XP_006235647.1

UniProtKB/TrEMBL

A0A8I6AAW4, A0A8L2QQ52, A6JX58

Related

ENSRNOP00000089109.1

Conserved Domains (3) summary

sd00006
Location:193 → 221

TPR; TPR repeat [structural motif]

pfam00515
Location:229 → 260

TPR_1; Tetratricopeptide repeat

pfam13414
Location:192 → 257

TPR_11; TPR repeat