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    TUG1 taurine up-regulated 1 [ Homo sapiens (human) ]

    Gene ID: 55000, updated on 6-May-2024

    Summary

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    Official Symbol
    TUG1provided by HGNC
    Official Full Name
    taurine up-regulated 1provided by HGNC
    Primary source
    HGNC:HGNC:26066
    See related
    Ensembl:ENSG00000253352 MIM:614971; AllianceGenome:HGNC:26066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TI-227H; LINC00080; NCRNA00080
    Summary
    Predicted to act upstream of or within photoreceptor cell development and regulation of gene expression. Predicted to be active in nucleus. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 36.1), endometrium (RPKM 31.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TUG1 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30969265..30979395)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31432823..31442955)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31365251..31375381)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene uncharacterized LOC107985544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18846 Neighboring gene eukaryotic translation initiation factor 4H pseudogene 2 Neighboring gene MORC2 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:31335586-31335801 Neighboring gene MORC family CW-type zinc finger 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13620 Neighboring gene MPRA-validated peak4481 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31439932-31440502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31440503-31441072 Neighboring gene RNA, 7SL, cytoplasmic 633, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31481712-31482338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31492256-31492830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31492831-31493404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31499788-31500738 Neighboring gene smoothelin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncTUG1 contributes to the progression of hepatocellular carcinoma via the miR-144-3p/RRAGD axis and mTOR/S6K pathway. Chen W, et al. Sci Rep, 2023 May 9. PMID 37160972, Free PMC Article
    2. LncRNA TUG1 relieves renal mesangial cell injury by modulating the miR-153-3p/Bcl-2 axis in lupus nephritis. Liu L, et al. Immun Inflamm Dis, 2023 Apr. PMID 37102641, Free PMC Article
    3. Expression of oncolong noncoding RNA taurine-upregulated gene-1 in colon cancer: A clinical study supported by in silico analysis. Abushouk AI, et al. J Cancer Res Ther, 2022 Dec. PMID 36510991
    4. Overexpression of lncRNA TUG1 enhances the efficacy of DC-CIK immunotherapy in neuroblastoma in vitro and in vivo. Tan WQ, et al. Cancer Biomark, 2023. PMID 36373305
    5. Aging-regulated TUG1 is dispensable for endothelial cell function. Gimbel AT, et al. PLoS One, 2022. PMID 36173935, Free PMC Article

    See all (226) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aerobic exercise suppresses cognitive injury in patients with Alzheimer's disease by regulating long non-coding RNA TUG1.
      Title: Aerobic exercise suppresses cognitive injury in patients with Alzheimer's disease by regulating long non-coding RNA TUG1.
    2. Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1).
      Title: Increased ferroptosis in leukocytes from preeclamptic women involving the long non-coding taurine upregulated gene 1 (TUG1).
    3. [Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease].
      Title: [Long Noncoding RNAs MEG3, TUG1, and hsa-miR-21-3p Are Potential Diagnostic Biomarkers for Coronary Artery Disease].
    4. The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index.
      Title: The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index.
    5. Interplay of LncRNA TUG1 and TGF-beta/P53 Expression in Colorectal Cancer.
      Title: Interplay of LncRNA TUG1 and TGF-β/P53 Expression in Colorectal Cancer.
    6. LncTUG1 promotes hepatocellular carcinoma immune evasion via upregulating PD-L1 expression.
      Title: LncTUG1 promotes hepatocellular carcinoma immune evasion via upregulating PD-L1 expression.
    7. Long non-coding RNAs TUG1 and MEG3 in patients with type 2 diabetes and their association with endoplasmic reticulum stress markers.
      Title: Long non-coding RNAs TUG1 and MEG3 in patients with type 2 diabetes and their association with endoplasmic reticulum stress markers.
    8. YY1-induced LncRNA-TUG1 elevates YOD1 to promote cell proliferation and inhibit bortezomib sensitivity in multiple myeloma.
      Title: YY1-induced LncRNA-TUG1 elevates YOD1 to promote cell proliferation and inhibit bortezomib sensitivity in multiple myeloma.
    9. LncTUG1 contributes to the progression of hepatocellular carcinoma via the miR-144-3p/RRAGD axis and mTOR/S6K pathway.
      Title: LncTUG1 contributes to the progression of hepatocellular carcinoma via the miR-144-3p/RRAGD axis and mTOR/S6K pathway.
    10. LncRNA TUG1 relieves renal mesangial cell injury by modulating the miR-153-3p/Bcl-2 axis in lupus nephritis.
      Title: LncRNA TUG1 relieves renal mesangial cell injury by modulating the miR-153-3p/Bcl-2 axis in lupus nephritis.
    Submit: New GeneRIF Correction See all GeneRIFs (201)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20618, MGC46067

    General protein information

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    Preferred Names
    taurine up-regulated 1
    Names
    taurine upregulated gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396518.1 → NP_001383447.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40
      Related
      ENSP00000501406.2, ENST00000644773.3

    2. NM_001398476.1 → NP_001385405.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    3. NM_001398477.1 → NP_001385406.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    4. NM_001398478.1 → NP_001385407.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    5. NM_001398479.1 → NP_001385408.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40
      Related
      ENST00000643071.1

    6. NM_001398480.1 → NP_001385409.1  taurine up-regulated 1

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Consensus CDS
      CCDS93148.1
      UniProtKB/Swiss-Prot
      A0A6I8PU40

    RNA

    1. NR_152867.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004542
      Related
      ENST00000646496.1

    2. NR_152868.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC004542

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30969265..30979395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31432823..31442955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_017903.2: Suppressed sequence

      Description
      NM_017903.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NR_002323.3: Suppressed sequence

      Description
      NR_002323.3: This RefSeq was removed because it is now thought that this gene does encode a protein.

    3. NR_110493.2: Suppressed sequence

      Description
      NR_110493.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version

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