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    ANGPTL7 angiopoietin like 7 [ Homo sapiens (human) ]

    Gene ID: 10218, updated on 23-Mar-2024

    Summary

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    Official Symbol
    ANGPTL7provided by HGNC
    Official Full Name
    angiopoietin like 7provided by HGNC
    Primary source
    HGNC:HGNC:24078
    See related
    Ensembl:ENSG00000171819 MIM:618517; AllianceGenome:HGNC:24078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AngX; CDT6; dJ647M16.1
    Summary
    Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart (RPKM 2.5), gall bladder (RPKM 2.2) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANGPTL7 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11189355..11195981)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10730945..10737571)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11249412..11256038)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene RNA, U6 small nuclear 537, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:11237905-11238443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11249765-11250265 Neighboring gene MPRA-validated peak73 silencer Neighboring gene RNA, U6 small nuclear 291, pseudogene Neighboring gene ribosomal protein L39 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity. Leentjens M, et al. Front Endocrinol (Lausanne), 2022. PMID 36017324, Free PMC Article
    2. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. Xia X, et al. Biomed Res Int, 2020. PMID 33313310, Free PMC Article
    3. Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell. Li J, et al. Gen Physiol Biophys, 2020 May. PMID 32525822
    4. Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. Tanigawa Y, et al. PLoS Genet, 2020 May. PMID 32369491, Free PMC Article
    5. Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure. Zhang C, et al. Cardiorenal Med, 2020. PMID 31962333

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ANGPTL7 and Its Role in IOP and Glaucoma.
      Title: ANGPTL7 and Its Role in IOP and Glaucoma.
    2. The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
      Title: The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
    3. Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.
      Title: Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.
    4. Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.
      Title: Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.
    5. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
      Title: ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
    6. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity.
      Title: Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity.
    7. Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure.
      Title: Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure.
    8. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.
      Title: Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.
    9. Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
      Title: Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
    10. Angiopoietin-like protein 7 mediates TNF-alpha-induced adhesion and oxidative stress in human umbilical vein epithelial cell.
      Title: Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of vasculature development involved in avascular cornea development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    angiopoietin-related protein 7
    Names
    angiopoietin-like factor (CDT6)
    angiopoietin-like protein 7
    cornea-derived transcript 6 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021146.4 → NP_066969.1  angiopoietin-related protein 7 precursor

      See identical proteins and their annotated locations for NP_066969.1

      Status: VALIDATED

      Source sequence(s)
      BC001881
      Consensus CDS
      CCDS128.1
      UniProtKB/Swiss-Prot
      B2R9B2, F1T0A6, O43827, Q4ZGK4
      Related
      ENSP00000366015.3, ENST00000376819.4
      Conserved Domains (2) summary
      cd00087
      Location:129 → 341
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      cl25732
      Location:37 → 109
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11189355..11195981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424430.1 → XP_047280386.1  angiopoietin-related protein 7 isoform X2

    2. XM_017000004.2 → XP_016855493.1  angiopoietin-related protein 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      10730945..10737571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333755.1 → XP_054189730.1  angiopoietin-related protein 7 isoform X2

    2. XM_054333754.1 → XP_054189729.1  angiopoietin-related protein 7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43827.1 GenPept UniProtKB/Swiss-Prot:O43827

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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