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    AQP4 aquaporin 4 [ Canis lupus familiaris (dog) ]

    Gene ID: 612628, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AQP4provided by VGNC
    Official Full Name
    aquaporin 4provided by VGNC
    Primary source
    VGNC:VGNC:38018
    See related
    Ensembl:ENSCAFG00845012372
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See AQP4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (61906422..61919761)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (61290817..61304150)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (61894861..61908198)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (61579168..61592459)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (61591530..61604873)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 9 Neighboring gene uncharacterized LOC102155178 Neighboring gene uncharacterized LOC111096788 Neighboring gene uncharacterized LOC111096790 Neighboring gene potassium channel tetramerization domain containing 1 Neighboring gene homeobox protein CDX-4-like Neighboring gene TATA-box binding protein associated factor 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting. Schmidt MJ, et al. Fluids Barriers CNS, 2016 Jun 29. PMID 27357498, Free PMC Article
    2. Measuring localization and diffusion coefficients of basolateral proteins in lateral versus basal membranes using functionalized substrates and kICS analysis. Marlar S, et al. Biochim Biophys Acta, 2014 Oct. PMID 24950246
    3. Aquaporin-3 and aquaporin-4 are sorted differently and separately in the trans-Golgi network. Arnspang EC, et al. PLoS One, 2013. PMID 24058510, Free PMC Article
    4. Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. Tham DK, et al. Am J Physiol Renal Physiol, 2011 Aug. PMID 21543416, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An increase in ventricular dimension is accompanied by increases in AQP4 and IL-6 concentrations in the CSF of dogs with idiopathic communicating hydrocephalus. All were greatly reduced or normalised after shunt treatment. Therefore AQP4 and IL-6 in CSF can be indicators of ventriculomegaly, of cellular damage, and of improvement after the treatment of hydrocephalus.
      Title: Increased CSF aquaporin-4, and interleukin-6 levels in dogs with idiopathic communicating internal hydrocephalus and a decrease after ventriculo-peritoneal shunting.
    2. AQP3-EGFP was predominantly localized to "lateral" compared to "basal" membranes, whereas Orange-AQP4 was evenly distributed.
      Title: Measuring localization and diffusion coefficients of basolateral proteins in lateral versus basal membranes using functionalized substrates and kICS analysis.
    3. AQP3 and AQP4 are separated into different post-Golgi carriers based on different cytoplasmic domain sorting signals, and are then delivered separately to the plasma membrane.
      Title: Aquaporin-3 and aquaporin-4 are sorted differently and separately in the trans-Golgi network.
    4. interaction of dystroglycan and integrins with the extracellular matrix plays an important role in the polarized distribution of Kir4.1 and AQP4 at the basolateral domain of kidney epithelial cells
      Title: Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables water channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aquaporin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      61906422..61919761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038672420.1 → XP_038528348.1  aquaporin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R0F3, A0A8I3NCC0, A0A8I3RX19, A0A8P0PLW3, A0A8P0PNT7
      Related
      ENSCAFP00845017358.1, ENSCAFT00845022077.1
      Conserved Domains (1) summary
      pfam00230
      Location:31 → 248
      MIP; Major intrinsic protein

    2. XM_038672421.1 → XP_038528349.1  aquaporin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NCC0, A0A8P0PNT7
      Conserved Domains (1) summary
      pfam00230
      Location:9 → 226
      MIP; Major intrinsic protein

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      61579168..61592459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038482185.1 → XP_038338113.1  aquaporin-4 isoform X1

      Conserved Domains (1) summary
      pfam00230
      Location:31 → 248
      MIP; Major intrinsic protein

    2. XM_038482186.1 → XP_038338114.1  aquaporin-4 isoform X2

      Conserved Domains (1) summary
      pfam00230
      Location:9 → 226
      MIP; Major intrinsic protein

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      61591530..61604873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038607739.1 → XP_038463667.1  aquaporin-4 isoform X1

      Conserved Domains (1) summary
      pfam00230
      Location:31 → 248
      MIP; Major intrinsic protein

    2. XM_038607740.1 → XP_038463668.1  aquaporin-4 isoform X2

      Conserved Domains (1) summary
      pfam00230
      Location:9 → 226
      MIP; Major intrinsic protein

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      61894861..61908198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038543616.1 → XP_038399544.1  aquaporin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R0F3, A0A8I3NCC0, A0A8I3RX19, A0A8P0PLW3, A0A8P0PNT7
      Conserved Domains (1) summary
      pfam00230
      Location:31 → 248
      MIP; Major intrinsic protein

    2. XM_038543617.1 → XP_038399545.1  aquaporin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NCC0, A0A8P0PNT7
      Conserved Domains (1) summary
      pfam00230
      Location:9 → 226
      MIP; Major intrinsic protein

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      61290817..61304150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_850363.6 → XP_855456.2  aquaporin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8C0R0F3, A0A8I3NCC0, A0A8I3RX19, A0A8P0PLW3, A0A8P0PNT7
      Conserved Domains (1) summary
      pfam00230
      Location:31 → 248
      MIP; Major intrinsic protein

    2. XM_014115489.3 → XP_013970964.1  aquaporin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I3NCC0, A0A8P0PNT7
      Conserved Domains (1) summary
      pfam00230
      Location:9 → 226
      MIP; Major intrinsic protein
    Nucleotide Protein
    Heading Accession and Version

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