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    ZNF566 zinc finger protein 566 [ Homo sapiens (human) ]

    Gene ID: 84924, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF566provided by HGNC
    Official Full Name
    zinc finger protein 566provided by HGNC
    Primary source
    HGNC:HGNC:25919
    See related
    Ensembl:ENSG00000186017 AllianceGenome:HGNC:25919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.9), ovary (RPKM 1.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF566 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36445119..36489561, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39120063..39164789, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36936021..36980463, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZFP82 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36912605-36913287 Neighboring gene acyl-CoA thioesterase 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919277-36919778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919779-36920278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:36939953-36941152 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36979559-36980446 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332 Neighboring gene ZNF566 antisense RNA 1 Neighboring gene CTBP2 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    2. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
    3. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307
    4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
    5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14779, MGC12515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 566

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145343.1 → NP_001138815.1  zinc finger protein 566 isoform 2

      See identical proteins and their annotated locations for NP_001138815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting isoform (2) is one amino acid longer than isoform 1.
      Source sequence(s)
      AC092296, DC413210
      Consensus CDS
      CCDS46061.1
      UniProtKB/Swiss-Prot
      Q969W8
      Related
      ENSP00000400651.2, ENST00000427002.2
      Conserved Domains (6) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:254 → 405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:200 → 222
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001145344.1 → NP_001138816.1  zinc finger protein 566 isoform 1

      See identical proteins and their annotated locations for NP_001138816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC092295, AC092296, DC373988
      Consensus CDS
      CCDS12494.1
      UniProtKB/Swiss-Prot
      B7ZL95, Q2M3J1, Q969W8
      Related
      ENSP00000411526.2, ENST00000452939.7
      Conserved Domains (6) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      COG5048
      Location:253 → 404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001145345.1 → NP_001138817.1  zinc finger protein 566 isoform 1

      See identical proteins and their annotated locations for NP_001138817.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC092296, BC104888, BP351422
      Consensus CDS
      CCDS12494.1
      UniProtKB/Swiss-Prot
      B7ZL95, Q2M3J1, Q969W8
      Related
      ENSP00000401259.2, ENST00000424129.7
      Conserved Domains (6) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      COG5048
      Location:253 → 404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001300970.2 → NP_001287899.1  zinc finger protein 566 isoform 3

      See identical proteins and their annotated locations for NP_001287899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC092296, BC104888, BQ269572, DA116442, HY178567
      Consensus CDS
      CCDS74346.1
      UniProtKB/TrEMBL
      B4DRR6
      Conserved Domains (2) summary
      COG5048
      Location:149 → 300
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:153 → 173
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_032838.4 → NP_116227.1  zinc finger protein 566 isoform 1

      See identical proteins and their annotated locations for NP_116227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC092296, AK027685
      Consensus CDS
      CCDS12494.1
      UniProtKB/Swiss-Prot
      B7ZL95, Q2M3J1, Q969W8
      Related
      ENSP00000415520.2, ENST00000434377.6
      Conserved Domains (6) summary
      smart00349
      Location:6 → 65
      KRAB; krueppel associated box
      COG5048
      Location:253 → 404
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:199 → 221
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36445119..36489561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527428.2 → XP_011525730.1  zinc finger protein 566 isoform X4

      See identical proteins and their annotated locations for XP_011525730.1

      UniProtKB/TrEMBL
      B4DRR6
      Related
      ENSP00000465343.1, ENST00000493391.6
      Conserved Domains (2) summary
      COG5048
      Location:149 → 300
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:153 → 173
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_017027399.2 → XP_016882888.1  zinc finger protein 566 isoform X4

      UniProtKB/TrEMBL
      B4DRR6
      Conserved Domains (2) summary
      COG5048
      Location:149 → 300
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:153 → 173
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_005259354.3 → XP_005259411.1  zinc finger protein 566 isoform X2

      Conserved Domains (6) summary
      smart00349
      Location:6 → 48
      KRAB; krueppel associated box
      COG5048
      Location:221 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:167 → 189
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:237 → 262
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047439565.1 → XP_047295521.1  zinc finger protein 566 isoform X2

    5. XM_006723447.3 → XP_006723510.1  zinc finger protein 566 isoform X1

      See identical proteins and their annotated locations for XP_006723510.1

      UniProtKB/Swiss-Prot
      Q969W8
      Related
      ENSP00000376010.2, ENST00000392170.7
      Conserved Domains (6) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:254 → 405
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:200 → 222
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain

    6. XM_047439566.1 → XP_047295522.1  zinc finger protein 566 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      39120063..39164789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322439.1 → XP_054178414.1  zinc finger protein 566 isoform X4

      UniProtKB/TrEMBL
      B4DRR6

    2. XM_054322438.1 → XP_054178413.1  zinc finger protein 566 isoform X4

      UniProtKB/TrEMBL
      B4DRR6

    3. XM_054322435.1 → XP_054178410.1  zinc finger protein 566 isoform X2

    4. XM_054322436.1 → XP_054178411.1  zinc finger protein 566 isoform X2

    5. XM_054322434.1 → XP_054178409.1  zinc finger protein 566 isoform X1

    6. XM_054322437.1 → XP_054178412.1  zinc finger protein 566 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969W8.1 GenPept UniProtKB/Swiss-Prot:Q969W8

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