Noxa1 NADPH oxidase activator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Noxa1provided by RGD
Official Full Name: NADPH oxidase activator 1provided by RGD
Primary source: RGD:1306687
See related: Ensembl:ENSRNOG00000009286 AllianceGenome:RGD:1306687
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including SH3 domain binding activity; small GTPase binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in regulation of hydrogen peroxide metabolic process; regulation of respiratory burst; and superoxide anion generation. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytosol. Orthologous to human NOXA1 (NADPH oxidase activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 6.1), Uterus (RPKM 4.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28293643..28309828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7895488..7907011, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2299676..2309491, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NADPH oxidase activator activity	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NADPH oxidase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in regulation of hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADPH oxidase activator 1

Names: predicted NADPH oxidase activator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100171.1 → NP_001093641.1 NADPH oxidase activator 1

See identical proteins and their annotated locations for NP_001093641.1

Status: PROVISIONAL

Source sequence(s)

BR000299

UniProtKB/Swiss-Prot

A7E3N7

UniProtKB/TrEMBL

A6JT09

Related

ENSRNOP00000012375.5, ENSRNOT00000012375.6

Conserved Domains (4) summary

cd06411
Location:288 → 365

PB1_p51; The PB1 domain is present in the p51 protein, a homolog of the p67 protein. p51 plays an important role in NADPH oxidase activation during phagosytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical ...

COG0457
Location:12 → 154

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:38 → 66

TPR; TPR repeat [structural motif]

cl17036
Location:375 → 427

SH3; Src Homology 3 domain superfamily