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    Ptpn4 protein tyrosine phosphatase, non-receptor type 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246116, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ptpn4provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 4provided by RGD
    Primary source
    RGD:620712
    See related
    Ensembl:ENSRNOG00000002625 AllianceGenome:RGD:620712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glutamate receptor binding activity and non-membrane spanning protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human PTPN4 (protein tyrosine phosphatase non-receptor type 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 272.4), Adrenal (RPKM 179.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn4 in Genome Data Viewer
    Location:
    13q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (33324808..33504957, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (30772012..30952340, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (35678240..35858414, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene uncharacterized LOC134481550 Neighboring gene ankyrin repeat domain 49, pseudogene 2 Neighboring gene uncharacterized LOC134481551 Neighboring gene uncharacterized LOC120096199 Neighboring gene uncharacterized LOC134481620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4. Ge L, et al. Oxid Med Cell Longev, 2019. PMID 31178952, Free PMC Article
    2. Nonreceptor protein tyrosine and lipid phosphatases in type I fc(epsilon) receptor-mediated activation of mast cells and basophils. Heneberg P, et al. Int Arch Allergy Immunol, 2002 Aug. PMID 12218363
    3. Councils of Nursing Assistants (N.A.C's). Paradis R. Infirm Aux, 1992 Dec. PMID 1302241
    4. Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG. Park KW, et al. Gene, 2000 Oct 17. PMID 11054567
    5. The properties of the protein tyrosine phosphatase PTPMEG. Gu M, et al. J Biol Chem, 1996 Nov 1. PMID 8910369

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The overexpression of miR-181c-5p significantly attenuated the mRNA and protein expression of PTPN4 in H9C2 cardiomyocytes.
      Title: miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 4
    NP_001093949.1
    XP_017454155.1
    XP_017454156.1
    XP_038946250.1
    XP_038946253.1
    XP_038946256.1
    XP_038946257.1
    XP_038946258.1
    XP_063128090.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100479.3 → NP_001093949.1  tyrosine-protein phosphatase non-receptor type 4

      See identical proteins and their annotated locations for NP_001093949.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6K7X3
      Conserved Domains (5) summary
      smart00295
      Location:30 → 222
      B41; Band 4.1 homologues
      cd00992
      Location:515 → 602
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216 → 310
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam08736
      Location:323 → 365
      FA; FERM adjacent (FA)
      cl28904
      Location:641 → 914
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      33324808..33504957 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272020.1 → XP_063128090.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A599

    2. XM_017598667.3 → XP_017454156.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

      Related
      ENSRNOP00000088009.1

    3. XM_017598666.3 → XP_017454155.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

      UniProtKB/TrEMBL
      G3V6B9
      Related
      ENSRNOP00000003568.6
      Conserved Domains (5) summary
      smart00295
      Location:30 → 229
      B41; Band 4.1 homologues
      cd00992
      Location:522 → 609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:223 → 317
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam08736
      Location:330 → 372
      FA; FERM adjacent (FA)
      cl28904
      Location:648 → 921
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_039090322.2 → XP_038946250.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

      UniProtKB/TrEMBL
      G3V6B9
      Conserved Domains (5) summary
      smart00295
      Location:30 → 229
      B41; Band 4.1 homologues
      cd00992
      Location:522 → 609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:223 → 317
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam08736
      Location:330 → 372
      FA; FERM adjacent (FA)
      cl28904
      Location:648 → 921
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_039090329.1 → XP_038946257.1  tyrosine-protein phosphatase non-receptor type 4 isoform X6

      Conserved Domains (4) summary
      cd00992
      Location:269 → 356
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08736
      Location:77 → 119
      FA; FERM adjacent (FA)
      cl17171
      Location:10 → 64
      PH-like; Pleckstrin homology-like domain
      cl28904
      Location:395 → 668
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_039090330.2 → XP_038946258.1  tyrosine-protein phosphatase non-receptor type 4 isoform X6

      Conserved Domains (4) summary
      cd00992
      Location:269 → 356
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08736
      Location:77 → 119
      FA; FERM adjacent (FA)
      cl17171
      Location:10 → 64
      PH-like; Pleckstrin homology-like domain
      cl28904
      Location:395 → 668
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_039090328.2 → XP_038946256.1  tyrosine-protein phosphatase non-receptor type 4 isoform X5

      Conserved Domains (5) summary
      smart00295
      Location:18 → 55
      B41; Band 4.1 homologues
      cd00992
      Location:348 → 435
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:49 → 143
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam08736
      Location:156 → 198
      FA; FERM adjacent (FA)
      cl28904
      Location:474 → 747
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_039090325.2 → XP_038946253.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

      Conserved Domains (5) summary
      smart00295
      Location:30 → 229
      B41; Band 4.1 homologues
      cd00992
      Location:522 → 609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:223 → 317
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam08736
      Location:330 → 372
      FA; FERM adjacent (FA)
      cl28904
      Location:648 → 904
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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