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    tufm Tu translation elongation factor, mitochondrial [ Danio rerio (zebrafish) ]

    Gene ID: 541378, updated on 27-Mar-2024

    Summary

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    Official Symbol
    tufmprovided by ZNC
    Official Full Name
    Tu translation elongation factor, mitochondrialprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-73
    See related
    Ensembl:ENSDARG00000104173 AllianceGenome:ZFIN:ZDB-GENE-050320-73
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    D250; fi06f04; wu:fi06f04; zgc:110766
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to act upstream of or within translation. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; optic tectum; pectoral fin bud; and segmental plate. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See tufm in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (13582019..13599471, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (13432173..13449625, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108182805 Neighboring gene noggin 5 Neighboring gene HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 Neighboring gene peptidoglycan recognition protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Lundby A, et al. Nat Methods, 2014 Aug. PMID 24952909, Free PMC Article
    2. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
    3. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor Tu, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013505.2 → NP_001013523.1  elongation factor Tu, mitochondrial

      See identical proteins and their annotated locations for NP_001013523.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091659
      UniProtKB/TrEMBL
      B2GSN2, Q5BJ17
      Related
      ENSDARP00000134914.1, ENSDART00000166639.2
      Conserved Domains (4) summary
      cd01884
      Location:51 → 245
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:42 → 435
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:253 → 339
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:342 → 434
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      13582019..13599471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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