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    mtpn myotrophin [ Danio rerio (zebrafish) ]

    Gene ID: 406240, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mtpnprovided by ZNC
    Official Full Name
    myotrophinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2166
    See related
    Ensembl:ENSDARG00000104018 AllianceGenome:ZFIN:ZDB-GENE-040426-2166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64078; wu:fa10f07
    Summary
    Predicted to be involved in regulation of barbed-end actin filament capping. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mtpn in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (1054708..1076053, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (1041260..1054700, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910363 Neighboring gene protein FAM180A Neighboring gene cholinergic receptor, muscarinic 2a Neighboring gene uncharacterized LOC108183355 Neighboring gene uncharacterized LOC103910364

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Quadruple zebrafish mutant reveals different roles of Mesp genes in somite segmentation between mouse and zebrafish. Yabe T, et al. Development, 2016 Aug 1. PMID 27385009, Free PMC Article
    2. Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia. Wang M, et al. Gen Comp Endocrinol, 2019 Oct 1. PMID 31299224
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in regulation of barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myotrophin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212972.2 → NP_998137.1  myotrophin

      See identical proteins and their annotated locations for NP_998137.1

      Status: VALIDATED

      Source sequence(s)
      CR548631, EB940788, EH440876, EH524721
      UniProtKB/Swiss-Prot
      Q7T2B9
      Related
      ENSDARP00000141690.1, ENSDART00000172320.2
      Conserved Domains (3) summary
      cd00204
      Location:6 → 117
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:6 → 97
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1 → 32
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      1054708..1076053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021474978.1 → XP_021330653.1  myotrophin isoform X1

      UniProtKB/TrEMBL
      A0A8M9PUB2
      Conserved Domains (2) summary
      cd00204
      Location:60 → 171
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:55 → 86
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T2B9.1 GenPept UniProtKB/Swiss-Prot:Q7T2B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.