itk IL2 inducible T cell kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itkprovided by ZNC
Official Full Name: IL2 inducible T cell kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-261
See related: Ensembl:ENSDARG00000017565 AllianceGenome:ZFIN:ZDB-GENE-990415-261
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Ptk; tec
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including NK T cell differentiation; antigen receptor-mediated signaling pathway; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within immune system process; intracellular signal transduction; and protein phosphorylation. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (34045284..34059663, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (33704970..33719349, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in NK T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase ITK/TSK

Names: tec-family kinase

NP_571179.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131104.1 → NP_571179.1 tyrosine-protein kinase ITK/TSK

See identical proteins and their annotated locations for NP_571179.1

Status: PROVISIONAL

Source sequence(s)

AF016326

UniProtKB/TrEMBL

O42200

Related

ENSDARP00000022015.5, ENSDART00000003993.7

Conserved Domains (6) summary

cd09934
Location:227 → 338

SH2_Tec_family; Src homology 2 (SH2) domain found in Tec-like proteins

cd11768
Location:170 → 223

SH3_Tec_like; Src Homology 3 domain of Tec-like Protein Tyrosine Kinases

cd01238
Location:7 → 147

PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

pfam00169
Location:5 → 110

PH; PH domain

pfam07714
Location:361 → 609

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:356 → 610

PKc_like; Protein Kinases, catalytic domain