psmb8a proteasome 20S subunit beta 8A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmb8aprovided by ZNC
Official Full Name: proteasome 20S subunit beta 8Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-141
See related: Ensembl:ENSDARG00000001303 AllianceGenome:ZFIN:ZDB-GENE-990415-141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lmp7; psmb8; beta5ia
Summary: Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to act upstream of or within proteolysis involved in cellular protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to human PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (7105838..7110580, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7186913..7191655, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome subunit beta type-8

Names: large multifunctional protease 7; macropain; proteasome (prosome, ) subunit, beta type, 8; proteasome (prosome, macropain) subunit, beta type, 8; proteasome (prosome, macropain) subunit, beta type, 8A; proteasome subunit beta 8A

NP_571467.3

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131392.3 → NP_571467.3 proteasome subunit beta type-8

See identical proteins and their annotated locations for NP_571467.3

Status: VALIDATED

Source sequence(s)

FP074889

UniProtKB/TrEMBL

B3DHT7, F6NLG9, O57330

Related

ENSDARP00000095608.3, ENSDART00000104838.5

Conserved Domains (2) summary

PTZ00488
Location:37 → 266

PTZ00488; Proteasome subunit beta type-5; Provisional

cd03761
Location:68 → 255

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...