Mtcl2 microtubule crosslinking factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtcl2provided by MGI
Official Full Name: microtubule crosslinking factor 2provided by MGI
Primary source: MGI:MGI:2444575
See related: Ensembl:ENSMUSG00000055485 AllianceGenome:MGI:2444575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Soga; Soga1; 9830001H06Rik; D430036N24Rik
Summary: Involved in insulin receptor signaling pathway; negative regulation of gluconeogenesis; and regulation of autophagy. Located in extracellular space. Orthologous to human SOGA1 (suppressor of glucose, autophagy associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 16.8), lung adult (RPKM 13.8) and 26 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2 H1; 2 77.91 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156852361..156921185, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (157010441..157079667, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: microtubule cross-linking factor 2

Names: SOGA family member 1; protein SOGA1; suppressor of glucose by autophagy; suppressor of glucose, autophagy associated 1; suppressor of glucose, autophagy-associated protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164663.1 → NP_001158135.1 microtubule cross-linking factor 2

Status: VALIDATED

Source sequence(s)

AK147227, AL669932, CJ164427

Consensus CDS

CCDS50781.1

UniProtKB/Swiss-Prot

A2ACV6, E1U8D0

Related

ENSMUSP00000066556.7, ENSMUST00000069098.7

Conserved Domains (3) summary

pfam00261
Location:294 → 555

Tropomyosin; Tropomyosin

pfam11365
Location:378 → 472

DUF3166; Protein of unknown function (DUF3166)

pfam14818
Location:1065 → 1202

DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

156852361..156921185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319023.3 → XP_017174512.3 microtubule cross-linking factor 2 isoform X2

Conserved Domains (5) summary

PHA03307
Location:28 → 211

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:214 → 548

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:251 → 1090

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam11365
Location:504 → 593

SOGA; Protein SOGA

pfam14818
Location:1018 → 1156

DUF4482; Domain of unknown function (DUF4482)
XM_036162310.1 → XP_036018203.1 microtubule cross-linking factor 2 isoform X1

Conserved Domains (5) summary

PHA03307
Location:28 → 211

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:214 → 548

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:251 → 1108

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam11365
Location:504 → 593

SOGA; Protein SOGA

pfam14818
Location:1065 → 1201

DUF4482; Domain of unknown function (DUF4482)