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    Akr1e2 aldo-keto reductase family 1, member E2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307091, updated on 2-May-2024

    Summary

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    Official Symbol
    Akr1e2provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member E2provided by RGD
    Primary source
    RGD:1309599
    See related
    Ensembl:ENSRNOG00000017165 AllianceGenome:RGD:1309599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akr1e1; Akr1cl2
    Summary
    Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be active in cytosol. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 323.0), Kidney (RPKM 248.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akr1e2 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70645835..70660366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65735909..65750441)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69365437..69379944)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348616 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 9 Neighboring gene aldo-keto reductase family 1, member C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis. Azuma Y, et al. Mol Hum Reprod, 2004 Jul. PMID 15118078
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105536

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1,5-anhydro-D-fructose reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1,5-anhydro-D-fructose reductase
    Names
    AF reductase
    aldo-keto reductase family 1 member C-like protein 2
    aldo-keto reductase family 1, member C-like 2
    aldo-keto reductase family 1, member E1
    NP_001008343.1
    XP_008770087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008342.1 → NP_001008343.1  1,5-anhydro-D-fructose reductase

      See identical proteins and their annotated locations for NP_001008343.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086397
      UniProtKB/Swiss-Prot
      Q5U1Y4
      UniProtKB/TrEMBL
      A0A8I6GF05
      Related
      ENSRNOP00000023133.5, ENSRNOT00000023133.8
      Conserved Domains (2) summary
      COG0656
      Location:4 → 282
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:4 → 287
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      70645835..70660366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771865.3 → XP_008770087.1  1,5-anhydro-D-fructose reductase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GF05
      Conserved Domains (2) summary
      COG0656
      Location:4 → 243
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:4 → 248
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U1Y4.1 GenPept UniProtKB/Swiss-Prot:Q5U1Y4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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