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    DCUN1D2 defective in cullin neddylation 1 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 55208, updated on 3-Apr-2024

    Summary

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    Official Symbol
    DCUN1D2provided by HGNC
    Official Full Name
    defective in cullin neddylation 1 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:20328
    See related
    Ensembl:ENSG00000150401 AllianceGenome:HGNC:20328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCNL2; C13orf17
    Summary
    Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart (RPKM 8.1), testis (RPKM 2.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCUN1D2 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113455819..113491563, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112714662..112750406, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114110134..114145026, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114032969-114033953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114047778-114048319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5546 Neighboring gene Sharpr-MPRA regulatory region 10007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114059695-114060489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114061607-114062292 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114064726-114065925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114071164-114072164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114072165-114073165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114075358-114076070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114076783-114077494 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114080191-114080738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114085068-114085648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114100205-114101146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114105835-114106336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114110333-114111263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene transcription factor Dp-1 Neighboring gene uncharacterized LOC124903219 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. Monda JK, et al. Structure, 2013 Jan 8. PMID 23201271, Free PMC Article
    2. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Meyer-Schaller N, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19617556, Free PMC Article
    3. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. Keuss MJ, et al. J Cell Sci, 2016 Apr 1. PMID 26906416, Free PMC Article
    4. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz T, et al. Nature, 2005 Jun 30. PMID 15988528
    5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. Charlaftis N, et al. EMBO J, 2014 Nov 3. PMID 25260751, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10704, FLJ20092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 2
    Names
    DCN1, defective in cullin neddylation 1, domain containing 2
    DCUN1 domain-containing protein 2
    defective in cullin neddylation protein 1-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014283.2 → NP_001014305.1  DCN1-like protein 2

      See identical proteins and their annotated locations for NP_001014305.1

      Status: VALIDATED

      Source sequence(s)
      AK000099, AK001566, AL442125, BM836766
      Consensus CDS
      CCDS32013.1
      UniProtKB/Swiss-Prot
      Q5JSA5, Q5JSA6, Q5JSA7, Q6PH85, Q9NVJ1, Q9NXR6
      Related
      ENSP00000417706.1, ENST00000478244.6
      Conserved Domains (2) summary
      cd14412
      Location:2 → 48
      UBA_DCNL2; UBA-like domain found in DCN1-like protein 2 (DCNL2) and similar proteins
      pfam03556
      Location:136 → 246
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      113455819..113491563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020647.2 → XP_016876136.1  DCN1-like protein 2 isoform X2

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    2. XM_017020649.2 → XP_016876138.2  DCN1-like protein 2 isoform X3

      Related
      ENSP00000330629.3, ENST00000332592.7

    3. XM_017020644.2 → XP_016876133.1  DCN1-like protein 2 isoform X2

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    4. XM_017020643.2 → XP_016876132.1  DCN1-like protein 2 isoform X1

    5. XM_017020646.3 → XP_016876135.1  DCN1-like protein 2 isoform X2

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    6. XM_047430432.1 → XP_047286388.1  DCN1-like protein 2 isoform X2

    7. XM_047430431.1 → XP_047286387.1  DCN1-like protein 2 isoform X2

    RNA

    1. XR_007063687.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      112714662..112750406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374656.1 → XP_054230631.1  DCN1-like protein 2 isoform X2

    2. XM_054374657.1 → XP_054230632.1  DCN1-like protein 2 isoform X3

    3. XM_054374654.1 → XP_054230629.1  DCN1-like protein 2 isoform X2

    4. XM_054374651.1 → XP_054230626.1  DCN1-like protein 2 isoform X1

    5. XM_054374655.1 → XP_054230630.1  DCN1-like protein 2 isoform X2

    6. XM_054374653.1 → XP_054230628.1  DCN1-like protein 2 isoform X2

    7. XM_054374652.1 → XP_054230627.1  DCN1-like protein 2 isoform X2

    RNA

    1. XR_008488769.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018185.2: Suppressed sequence

      Description
      NM_018185.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PH85.1 GenPept UniProtKB/Swiss-Prot:Q6PH85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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