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    RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 484648, updated on 5-Mar-2024

    Summary

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    Official Symbol
    RAF1provided by VGNC
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:45325
    See related
    Ensembl:ENSCAFG00845028676
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See RAF1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (5921808..6000868)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (5929501..6009310)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (5966879..6046000)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (5637969..5717035)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (5991105..6070948)

    Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene cullin associated and neddylation dissociated 2 (putative) Neighboring gene transmembrane protein 40 Neighboring gene makorin ring finger protein 2 Neighboring gene thymosin beta-4-like Neighboring gene replication protein A 32 kDa subunit-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    v-raf-1 murine leukemia viral oncogene homolog 1
    XP_005632198.1
    XP_022262065.1
    XP_022262066.1
    XP_038282819.1
    XP_038282820.1
    XP_038282821.1
    XP_038282822.1
    XP_038282823.1
    XP_038311911.1
    XP_038358616.1
    XP_038358617.1
    XP_038358618.1
    XP_038358619.1
    XP_038358620.1
    XP_038421534.1
    XP_038421535.1
    XP_038421536.1
    XP_038421537.1
    XP_038421538.1
    XP_038485666.1
    XP_038485667.1
    XP_038485668.1
    XP_038485670.1
    XP_038485671.1
    XP_859234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051824.1 Reference ROS_Cfam_1.0

      Range
      5921808..6000868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038426891.1 → XP_038282819.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Related
      ENSCAFP00845039725.1, ENSCAFT00845050674.1
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    2. XM_038426893.1 → XP_038282821.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
      Related
      ENSCAFP00845039751.1, ENSCAFT00845050706.1
      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    3. XM_038426892.1 → XP_038282820.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    4. XM_038426894.1 → XP_038282822.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_038426895.1 → XP_038282823.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049280.1 Alternate UMICH_Zoey_3.1

      Range
      5637969..5717035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038502688.1 → XP_038358616.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    2. XM_038502690.1 → XP_038358618.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    3. XM_038502689.1 → XP_038358617.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    4. XM_038502691.1 → XP_038358619.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_038502692.1 → XP_038358620.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

      Range
      5991105..6070948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038629738.1 → XP_038485666.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    2. XM_038629740.1 → XP_038485668.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    3. XM_038629739.1 → XP_038485667.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    4. XM_038629742.1 → XP_038485670.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_038629743.1 → XP_038485671.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

      Range
      5966879..6046000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038565606.1 → XP_038421534.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    2. XM_038565608.1 → XP_038421536.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    3. XM_038565607.1 → XP_038421535.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    4. XM_038565609.1 → XP_038421537.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_038565610.1 → XP_038421538.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      5929501..6009310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005632141.1 → XP_005632198.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    2. XM_854141.3 → XP_859234.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    3. XM_022406357.1 → XP_022262065.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    4. XM_038455983.1 → XP_038311911.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_022406358.1 → XP_022262066.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I3Q532, A0A8P0NRR2
      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd20870
      Location:55 → 106
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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