DEFB1 defensin beta 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DEFB1provided by VGNC
Official Full Name: defensin beta 1provided by VGNC
Primary source: VGNC:VGNC:39876
See related: Ensembl:ENSCAFG00845021822
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CBD1
Orthologs: human all
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Genomic context

Location:: chromosome: 16

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	16	NC_051820.1 (57167155..57177835)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	16	NC_006598.4 (54396123..54406697, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	16	NC_049237.1 (55550404..55561006)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	16	NC_049276.1 (59031889..59042480, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	16	NC_049757.1 (55175446..55186038)

Chromosome 16 - NC_051820.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study demonstrates a possible association between SNPs in the CBD1 gene and Leishmania infantum infection in dogs
Title: Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs.
Data show thatc ontrary to cBD1, expression of cBD103 was slightly (2-fold) downregulated in skin of atopic dogs.
Title: Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR6 chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-defensin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.