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    P4HA1 prolyl 4-hydroxylase subunit alpha 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 479242, updated on 5-Mar-2024

    Summary

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    Official Symbol
    P4HA1provided by VGNC
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:44222
    See related
    Ensembl:ENSCAFG00845006050
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See P4HA1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (23886920..23964071, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (23738890..23816335, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (24339447..24416949, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (23785865..23863342, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (23984840..24062302, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene protein AMN1 homolog Neighboring gene enolase-phosphatase E1-like Neighboring gene nudix hydrolase 13 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene family with sequence similarity 149 member B1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-1
    Names
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
    XP_005619063.1
    XP_005619064.1
    XP_038329170.1
    XP_038329171.1
    XP_038329172.1
    XP_038390235.1
    XP_038390236.1
    XP_038390237.1
    XP_038454554.1
    XP_038454555.1
    XP_038454556.1
    XP_038518832.1
    XP_038518833.1
    XP_038518834.1
    XP_850682.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      23886920..23964071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662906.1 → XP_038518834.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PSC4, A0A8C0R7J4, A0A8I3N1J1
      Related
      ENSCAFP00845008361.1, ENSCAFT00845010723.1
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038662905.1 → XP_038518833.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038662904.1 → XP_038518832.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Related
      ENSCAFP00845008375.1, ENSCAFT00845010738.1
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RNA

    1. XR_005425556.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      23785865..23863342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473244.1 → XP_038329172.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038473243.1 → XP_038329171.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038473242.1 → XP_038329170.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RNA

    1. XR_005324150.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      23984840..24062302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598628.1 → XP_038454556.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038598627.1 → XP_038454555.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038598626.1 → XP_038454554.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RNA

    1. XR_005392466.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      24339447..24416949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534309.1 → XP_038390237.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PSC4, A0A8C0R7J4, A0A8I3N1J1
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_038534308.1 → XP_038390236.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_038534307.1 → XP_038390235.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RNA

    1. XR_005357958.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23738890..23816335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005619007.4 → XP_005619064.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PSC4, A0A8C0R7J4, A0A8I3N1J1
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    2. XM_005619006.4 → XP_005619063.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_005619063.1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_845589.6 → XP_850682.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_850682.1

      UniProtKB/TrEMBL
      A0A8C0MVU6, A0A8C0PN19, A0A8I3RT21, A0A8I3RUH8
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RNA

    1. XR_002625716.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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