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    CD80 CD80 molecule [ Canis lupus familiaris (dog) ]

    Gene ID: 403765, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CD80provided by VGNC
    Official Full Name
    CD80 moleculeprovided by VGNC
    Primary source
    VGNC:VGNC:38975
    See related
    Ensembl:ENSCAFG00845016834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CD80 in Genome Data Viewer
    Location:
    chromosome: 33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 33 NC_051837.1 (23415441..23446725, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 33 NC_006615.4 (23207369..23231610, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 33 NC_049254.1 (23822928..23847156, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 33 NC_049293.1 (23217902..23242129, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 33 NC_049774.1 (23253474..23277692, complement)

    Chromosome 33 - NC_051837.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 1 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene phospholipase A1 member A Neighboring gene uncharacterized LOC119867335 Neighboring gene popeye domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New forms of dog CD80 and CD86 transcripts that encode secreted B7 molecules. Yang S, et al. Immunogenetics, 1999 Dec. PMID 10630300

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    B7-1 protein
    CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
    T-cell co-stimulatory protein B7-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003147.1 → NP_001003147.1  T-lymphocyte activation antigen CD80 precursor

      See identical proteins and their annotated locations for NP_001003147.1

      Status: PROVISIONAL

      Source sequence(s)
      AF106824
      UniProtKB/TrEMBL
      A0A8C0K129, A0A8C0TR52, Q9TQX1
      Conserved Domains (3) summary
      cd00096
      Location:36 → 41
      Ig; Ig strand A [structural motif]
      cd16083
      Location:142 → 232
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 139
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051837.1 Reference ROS_Cfam_1.0

      Range
      23415441..23446725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038444567.1 → XP_038300495.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K129, A0A8C0TR52, Q9TQX1
      Related
      ENSCAFP00845023436.1, ENSCAFT00845029840.1
      Conserved Domains (3) summary
      cd00096
      Location:36 → 41
      Ig; Ig strand A [structural motif]
      cd16083
      Location:142 → 232
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 139
      Ig; Immunoglobulin domain

    2. XM_038444568.1 → XP_038300496.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K129, A0A8C0TR52, Q9TQX1
      Conserved Domains (3) summary
      cd00096
      Location:36 → 41
      Ig; Ig strand A [structural motif]
      cd16083
      Location:142 → 232
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 139
      Ig; Immunoglobulin domain

    3. XM_038444569.1 → XP_038300497.1  T-lymphocyte activation antigen CD80 isoform X2

      Conserved Domains (3) summary
      cd00096
      Location:36 → 41
      Ig; Ig strand A [structural motif]
      cd16083
      Location:142 → 232
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 139
      Ig; Immunoglobulin domain

    4. XM_038444566.1 → XP_038300494.1  T-lymphocyte activation antigen CD80 isoform X1

      UniProtKB/TrEMBL
      A0A8C0K129, A0A8C0TR52, Q9TQX1
      Conserved Domains (3) summary
      cd00096
      Location:36 → 41
      Ig; Ig strand A [structural motif]
      cd16083
      Location:142 → 232
      IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:35 → 139
      Ig; Immunoglobulin domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049293.1 Alternate UMICH_Zoey_3.1

      Range
      23217902..23242129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049774.1 Alternate UNSW_CanFamBas_1.0

      Range
      23253474..23277692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049254.1 Alternate UU_Cfam_GSD_1.0

      Range
      23822928..23847156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006615.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      23207369..23231610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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