TYR tyrosinase [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: TYRprovided by VGNC
Official Full Name: tyrosinaseprovided by VGNC
Primary source: VGNC:VGNC:48026
See related: Ensembl:ENSCAFG00845025889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	21	NC_051825.1 (10980195..11074816, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	21	NC_006603.4 (10649581..10749918, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	21	NC_049242.1 (10884281..10984898, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	21	NC_049281.1 (10768466..10862962, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	21	NC_049762.1 (10834102..10934647, complement)

Chromosome 21 - NC_051825.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the present study, the methods used were highly sensitive and specific for detection of tyrosinase expression in canine tumors, and overexpression of this transcript in melanomas was detected.
Title: Evaluation of tyrosinase expression in canine and equine melanocytic tumors.

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General gene information

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Markers

TYR (e-PCR), detects polymorphism
- UniSTS:264961

TYR (e-PCR), detects polymorphism
- UniSTS:266514

BAC_385-A9 (e-PCR)
- UniSTS:262681

GDB:177754 (e-PCR)
- UniSTS:154957

MARC_31609-31610:1062097014:1 (e-PCR)
- UniSTS:269208

GDB:177333 (e-PCR)
- UniSTS:154859

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tyrosinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in pigmentation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosinase

Names: monophenol monooxygenase; tyrosinase (oculocutaneous albinism IA)

NP_001002941.1

EC 1.14.18.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002941.1 → NP_001002941.1 tyrosinase precursor

See identical proteins and their annotated locations for NP_001002941.1

Status: PROVISIONAL

Source sequence(s)

AY336053

UniProtKB/Swiss-Prot

P54834, Q7YRB8

UniProtKB/TrEMBL

A0A8C0N2L2, A0A8C0TFG1, A0A8P0N746

Related

ENSCAFP00845035846.1, ENSCAFT00845045681.1

Conserved Domains (2) summary

pfam00264
Location:171 → 403

Tyrosinase; Common central domain of tyrosinase

cl21504
Location:88 → 113

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...