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    DOCK2 dedicator of cytokinesis 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 489128, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DOCK2provided by VGNC
    Official Full Name
    dedicator of cytokinesis 2provided by VGNC
    Primary source
    VGNC:VGNC:40046
    See related
    Ensembl:ENSCAFG00845002659
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DOCK2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (42156230..42590000, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (41732263..42129986, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (42671083..43068964, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (41973746..42371199, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (42160212..42557969, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095550 Neighboring gene uncharacterized LOC111095549 Neighboring gene forkhead box I1 Neighboring gene uncharacterized LOC119871510 Neighboring gene inhibitory synaptic factor family member 2B Neighboring gene protein INSYN2B-like Neighboring gene cyclin-G1-like Neighboring gene spindle apparatus coiled-coil protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      42156230..42590000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038663390.1 → XP_038519318.1  dedicator of cytokinesis protein 2

      UniProtKB/TrEMBL
      A0A8C0JUA1, A0A8C0LWD4, A0A8I3MQC8
      Related
      ENSCAFP00845003797.1, ENSCAFT00845004746.1
      Conserved Domains (4) summary
      cd11706
      Location:1200 → 1620
      DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
      cd12050
      Location:12 → 67
      SH3_DOCK2_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
      pfam16172
      Location:71 → 414
      DOCK_N; DOCK N-terminus
      cl14603
      Location:422 → 617
      C2; C2 domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      41973746..42371199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473703.1 → XP_038329631.1  dedicator of cytokinesis protein 2

      Conserved Domains (4) summary
      cd11706
      Location:1200 → 1620
      DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
      cd12050
      Location:12 → 67
      SH3_DOCK2_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
      pfam16172
      Location:71 → 414
      DOCK_N; DOCK N-terminus
      cl14603
      Location:422 → 617
      C2; C2 domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      42160212..42557969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038599084.1 → XP_038455012.1  dedicator of cytokinesis protein 2

      Conserved Domains (4) summary
      cd11706
      Location:1200 → 1620
      DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
      cd12050
      Location:12 → 67
      SH3_DOCK2_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
      pfam16172
      Location:71 → 414
      DOCK_N; DOCK N-terminus
      cl14603
      Location:422 → 617
      C2; C2 domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      42671083..43068964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534784.1 → XP_038390712.1  dedicator of cytokinesis protein 2

      UniProtKB/TrEMBL
      A0A8C0JUA1, A0A8C0LWD4, A0A8I3MQC8
      Conserved Domains (4) summary
      cd11706
      Location:1200 → 1620
      DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
      cd12050
      Location:12 → 67
      SH3_DOCK2_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
      pfam16172
      Location:71 → 414
      DOCK_N; DOCK N-terminus
      cl14603
      Location:422 → 617
      C2; C2 domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      41732263..42129986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_546246.6 → XP_546246.3  dedicator of cytokinesis protein 2

      UniProtKB/TrEMBL
      A0A8C0JUA1, A0A8C0LWD4, A0A8I3MQC8
      Conserved Domains (4) summary
      cd11706
      Location:1200 → 1620
      DHR2_DOCK2; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 2
      cd12050
      Location:12 → 67
      SH3_DOCK2_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis protein 2
      pfam16172
      Location:71 → 414
      DOCK_N; DOCK N-terminus
      cl14603
      Location:422 → 617
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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