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    OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF [ Canis lupus familiaris (dog) ]

    Gene ID: 482206, updated on 5-Mar-2024

    Summary

    Official Symbol
    OBSCNprovided by VGNC
    Official Full Name
    obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFprovided by VGNC
    Primary source
    VGNC:VGNC:49693
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See OBSCN in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    106
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (380493..503404, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (368668..495174)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (337710..460914, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (566842..694225, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (327479..475088, complement)

    Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106559712 Neighboring gene tripartite motif containing 17 Neighboring gene tripartite motif containing 11 Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene gap junction protein gamma 2

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    obscurin; LOW QUALITY PROTEIN: obscurin
    XP_038293789.1
    XP_038293790.1
    XP_038293791.1
    XP_038293793.1
    XP_038293798.1
    XP_038293806.1
    XP_038293808.1
    XP_038293813.1
    XP_038293816.1
    XP_038293824.1
    XP_038350051.1
    XP_038350052.1
    XP_038350053.1
    XP_038350054.1
    XP_038350055.1
    XP_038350056.1
    XP_038350057.1
    XP_038350058.1
    XP_038350059.1
    XP_038412346.1
    XP_038412347.1
    XP_038412348.1
    XP_038412349.1
    XP_038412350.1
    XP_038412351.1
    XP_038412352.1
    XP_038412353.1
    XP_038412354.1
    XP_038412356.1
    XP_038476289.1
    XP_038541974.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051818.1 Reference ROS_Cfam_1.0

      Range
      380493..503404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038686046.1XP_038541974.1  LOW QUALITY PROTEIN: obscurin isoform X1

      Conserved Domains (12) summary
      cd12025
      Location:56945756
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:76237701
      FN3; Fibronectin type 3 domain
      smart00409
      Location:37703847
      IG; Immunoglobulin
      smart00410
      Location:40424118
      IG_like; Immunoglobulin like
      cd00063
      Location:45764661
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:59746098
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:61066196
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57895965
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:65586814
      PKc_like; Protein Kinases, catalytic domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049274.1 Alternate UMICH_Zoey_3.1

      Range
      566842..694225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038494126.1XP_038350054.1  obscurin isoform X4

    2. XM_038494125.1XP_038350053.1  obscurin isoform X3

    3. XM_038494124.1XP_038350052.1  obscurin isoform X2

    4. XM_038494123.1XP_038350051.1  obscurin isoform X1

    5. XM_038494127.1XP_038350055.1  obscurin isoform X5

    6. XM_038494128.1XP_038350056.1  obscurin isoform X6

    7. XM_038494129.1XP_038350057.1  obscurin isoform X7

    8. XM_038494131.1XP_038350059.1  obscurin isoform X9

    9. XM_038494130.1XP_038350058.1  obscurin isoform X8

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

      Range
      327479..475088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038620361.1XP_038476289.1  LOW QUALITY PROTEIN: obscurin isoform X10

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

      Range
      337710..460914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038556423.1XP_038412351.1  obscurin isoform X16

    2. XM_038556421.1XP_038412349.1  obscurin isoform X14

    3. XM_038556420.1XP_038412348.1  obscurin isoform X13

    4. XM_038556419.1XP_038412347.1  obscurin isoform X12

    5. XM_038556418.1XP_038412346.1  obscurin isoform X11

    6. XM_038556422.1XP_038412350.1  obscurin isoform X15

    7. XM_038556424.1XP_038412352.1  obscurin isoform X17

    8. XM_038556425.1XP_038412353.1  obscurin isoform X18

    9. XM_038556428.1XP_038412356.1  obscurin isoform X20

    10. XM_038556426.1XP_038412354.1  obscurin isoform X19

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      368668..495174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038437861.1XP_038293789.1  obscurin isoform X21

      Conserved Domains (12) summary
      cd12025
      Location:57905852
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:77197797
      FN3; Fibronectin type 3 domain
      smart00409
      Location:38663943
      IG; Immunoglobulin
      smart00410
      Location:41384214
      IG_like; Immunoglobulin like
      cd00063
      Location:46724757
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:60706194
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:62026292
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:58856061
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:66546910
      PKc_like; Protein Kinases, catalytic domain
    2. XM_038437862.1XP_038293790.1  obscurin isoform X22

      Conserved Domains (12) summary
      cd12025
      Location:57905852
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:76567734
      FN3; Fibronectin type 3 domain
      smart00409
      Location:39574032
      IG; Immunoglobulin
      smart00410
      Location:38663943
      IG_like; Immunoglobulin like
      cd00063
      Location:46724757
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:60706194
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:62026292
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:58856061
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:65916847
      PKc_like; Protein Kinases, catalytic domain
    3. XM_038437878.1XP_038293806.1  obscurin isoform X26

      Conserved Domains (12) summary
      cd12025
      Location:56105672
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:75397617
      FN3; Fibronectin type 3 domain
      smart00409
      Location:41384214
      IG; Immunoglobulin
      smart00410
      Location:38663943
      IG_like; Immunoglobulin like
      cd00063
      Location:44924577
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:58906014
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:60226112
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57055881
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:64746730
      PKc_like; Protein Kinases, catalytic domain
    4. XM_038437865.1XP_038293793.1  obscurin isoform X24

      Conserved Domains (12) summary
      cd12025
      Location:56145676
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:75437621
      FN3; Fibronectin type 3 domain
      smart00409
      Location:36903767
      IG; Immunoglobulin
      smart00410
      Location:39624038
      IG_like; Immunoglobulin like
      cd00063
      Location:44964581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:58946018
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:60266116
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57095885
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:64786734
      PKc_like; Protein Kinases, catalytic domain
    5. XM_038437863.1XP_038293791.1  obscurin isoform X23

      Conserved Domains (12) summary
      cd12025
      Location:57025764
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:76317709
      FN3; Fibronectin type 3 domain
      smart00409
      Location:37783855
      IG; Immunoglobulin
      smart00410
      Location:40504126
      IG_like; Immunoglobulin like
      cd00063
      Location:45844669
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:59826106
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:61146204
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57975973
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:65666822
      PKc_like; Protein Kinases, catalytic domain
    6. XM_038437870.1XP_038293798.1  obscurin isoform X25

      Conserved Domains (12) summary
      cd12025
      Location:56145676
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:75437621
      FN3; Fibronectin type 3 domain
      smart00409
      Location:39624038
      IG; Immunoglobulin
      smart00410
      Location:36903767
      IG_like; Immunoglobulin like
      cd00063
      Location:44964581
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:58946018
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:60266116
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57095885
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:64786734
      PKc_like; Protein Kinases, catalytic domain
    7. XM_038437880.1XP_038293808.1  obscurin isoform X27

      Conserved Domains (11) summary
      cd12025
      Location:57905852
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:38663943
      IG; Immunoglobulin
      smart00410
      Location:30693145
      IG_like; Immunoglobulin like
      cd00063
      Location:46724757
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:60706194
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:62026292
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:58856061
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
      cl21453
      Location:66546844
      PKc_like; Protein Kinases, catalytic domain
    8. XM_038437885.1XP_038293813.1  obscurin isoform X28

      Conserved Domains (12) summary
      PHA03201
      Location:64326502
      PHA03201; uracil DNA glycosylase; Provisional
      smart00015
      Location:50535074
      IQ; Calmodulin-binding motif
      cd12025
      Location:57905852
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:44084481
      IG; Immunoglobulin
      smart00410
      Location:38663943
      IG_like; Immunoglobulin like
      cd00063
      Location:46724757
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:60706194
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:62026292
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:58856061
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
    9. XM_038437896.1XP_038293824.1  obscurin isoform X30

      Conserved Domains (12) summary
      PHA03201
      Location:62526322
      PHA03201; uracil DNA glycosylase; Provisional
      smart00015
      Location:48734894
      IQ; Calmodulin-binding motif
      cd12025
      Location:56105672
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:30693145
      IG; Immunoglobulin
      smart00410
      Location:38663943
      IG_like; Immunoglobulin like
      cd00063
      Location:44924577
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:58906014
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:60226112
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:57055881
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain
    10. XM_038437888.1XP_038293816.1  obscurin isoform X29

      Conserved Domains (11) summary
      smart00015
      Location:50535074
      IQ; Calmodulin-binding motif
      cd12025
      Location:57905852
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00409
      Location:38663943
      IG; Immunoglobulin
      smart00410
      Location:39574032
      IG_like; Immunoglobulin like
      cd00063
      Location:46724757
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd13239
      Location:60706194
      PH_Obscurin; Obscurin pleckstrin homology (PH) domain
      pfam07679
      Location:998
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:891893
      Ig; Ig strand A [structural motif]
      cd20971
      Location:62026292
      IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains
      cl02571
      Location:58856061
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl11960
      Location:891972
      Ig; Immunoglobulin domain