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    PKHD1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin [ Canis lupus familiaris (dog) ]

    Gene ID: 474934, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PKHD1provided by VGNC
    Official Full Name
    PKHD1 ciliary IPT domain containing fibrocystin/polyductinprovided by VGNC
    Primary source
    VGNC:VGNC:44605
    See related
    Ensembl:ENSCAFG00845007749
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PKHD1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (19781225..20253821, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (19173042..19651204, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (19530405..20000289, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (19289289..19759402, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (19392649..19862367, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106559576 Neighboring gene uncharacterized LOC111098281 Neighboring gene uncharacterized LOC111098282 Neighboring gene U4 spliceosomal RNA Neighboring gene keratin, type II cytoskeletal 8-like Neighboring gene 40S ribosomal protein S24-like Neighboring gene transcription factor BTF3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fibrocystin Is Essential to Cellular Control of Adhesion and Epithelial Morphogenesis. Ziegler WH, et al. Int J Mol Sci, 2020 Jul 20. PMID 32698519, Free PMC Article
    2. The transmembrane protein fibrocystin/polyductin regulates cell mechanics and cell motility. Puder S, et al. Phys Biol, 2019 Sep 18. PMID 31398719
    3. Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. Wang S, et al. Mol Cell Biol, 2007 Apr. PMID 17283055, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    fibrocystin; LOW QUALITY PROTEIN: fibrocystin
    Names
    PKHD1, fibrocystin/polyductin
    polycystic kidney and hepatic disease 1 (autosomal recessive)
    polycystic kidney and hepatic disease 1 protein
    polyductin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      19781225..20253821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038683752.1 → XP_038539680.1  fibrocystin

      UniProtKB/TrEMBL
      A0A8C0NWU7, A0A8I3N3J5
      Related
      ENSCAFP00845010972.1, ENSCAFT00845014155.1
      Conserved Domains (4) summary
      cd00603
      Location:1196 → 1289
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      pfam01833
      Location:1107 → 1191
      TIG; IPT/TIG domain
      pfam10162
      Location:1929 → 2047
      G8; G8 domain
      pfam13229
      Location:2998 → 3172
      Beta_helix; Right handed beta helix region

    RNA

    1. XR_005435611.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      19289289..19759402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038492035.1 → XP_038347963.1  LOW QUALITY PROTEIN: fibrocystin

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      19392649..19862367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038618163.1 → XP_038474091.1  fibrocystin

    RNA

    1. XR_005402194.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      19530405..20000289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554300.1 → XP_038410228.1  LOW QUALITY PROTEIN: fibrocystin

      UniProtKB/TrEMBL
      A0A8C0NWU7

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      19173042..19651204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005627465.3 → XP_005627522.1  fibrocystin

      UniProtKB/Swiss-Prot
      E2RK30
      UniProtKB/TrEMBL
      A0A8C0NWU7
      Conserved Domains (4) summary
      cd00603
      Location:1196 → 1289
      IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
      pfam01833
      Location:1107 → 1191
      TIG; IPT/TIG domain
      pfam10162
      Location:1929 → 2047
      G8; G8 domain
      pfam13229
      Location:2998 → 3172
      Beta_helix; Right handed beta helix region

    RNA

    1. XR_002631944.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2RK30.2 GenPept UniProtKB/Swiss-Prot:E2RK30

    Gene LinkOut

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