DOCK4 dedicator of cytokinesis 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DOCK4provided by VGNC
Official Full Name: dedicator of cytokinesis 4provided by VGNC
Primary source: VGNC:VGNC:40048
See related: Ensembl:ENSCAFG00845030164
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	14	NC_051818.1 (51494893..51905212, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	14	NC_006596.4 (50903465..51313338, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	14	NC_049235.1 (51565830..51975770, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	14	NC_049274.1 (51512246..51919885, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	14	NC_049755.1 (51195473..51603462, complement)

Chromosome 14 - NC_051818.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dedicator of cytokinesis protein 4; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051818.1 Reference ROS_Cfam_1.0

Range

51494893..51905212 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038687003.1 → XP_038542931.1 dedicator of cytokinesis protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I3Q2W8

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1727 → 1918

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_038687005.1 → XP_038542933.1 dedicator of cytokinesis protein 4 isoform X2

UniProtKB/TrEMBL

A0A8C0K1M2

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_038687004.1 → XP_038542932.1 dedicator of cytokinesis protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I3SCL9

Related

ENSCAFP00845042162.1, ENSCAFT00845053658.1

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1718 → 1909

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus

Alternate UMICH_Zoey_3.1

Genomic

NC_049274.1 Alternate UMICH_Zoey_3.1

Range

51512246..51919885 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038495103.1 → XP_038351031.1 dedicator of cytokinesis protein 4 isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049755.1 Alternate UNSW_CanFamBas_1.0

Range

51195473..51603462 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038621318.1 → XP_038477246.1 LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4 isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049235.1 Alternate UU_Cfam_GSD_1.0

Range

51565830..51975770 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038557373.1 → XP_038413301.1 dedicator of cytokinesis protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I3Q2W8

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1727 → 1918

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_038557375.1 → XP_038413303.1 dedicator of cytokinesis protein 4 isoform X2

UniProtKB/TrEMBL

A0A8C0K1M2

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_038557374.1 → XP_038413302.1 dedicator of cytokinesis protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I3SCL9

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1718 → 1909

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

50903465..51313338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005628739.4 → XP_005628796.1 dedicator of cytokinesis protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I3Q2W8

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1727 → 1918

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_005628740.4 → XP_005628797.1 dedicator of cytokinesis protein 4 isoform X2

UniProtKB/TrEMBL

A0A8C0K1M2

Conserved Domains (4) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1206 → 1596

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus
XM_539524.7 → XP_539524.4 dedicator of cytokinesis protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I3SCL9

Conserved Domains (5) summary

cd08695
Location:400 → 584

C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins

cd11705
Location:1197 → 1587

DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4

cd12049
Location:10 → 65

SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4

PHA03307
Location:1718 → 1909

PHA03307; transcriptional regulator ICP4; Provisional

pfam16172
Location:69 → 392

DOCK_N; DOCK N-terminus