NOX4 NADPH oxidase 4 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NOX4provided by VGNC
Official Full Name: NADPH oxidase 4provided by VGNC
Primary source: VGNC:VGNC:43905
See related: Ensembl:ENSCAFG00845025676
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	21	NC_051825.1 (10796288..10963304)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	21	NC_006603.4 (10465855..10632710)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	21	NC_049242.1 (10699999..10861437)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	21	NC_049281.1 (10584756..10745644)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	21	NC_049762.1 (10643276..10811261)

Chromosome 21 - NC_051825.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

REN108G11 (e-PCR)
- UniSTS:264226

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NADPH oxidase 4

XP_038285735.1

EC 1.6.3.-

EC 1.6.3.1

XP_038285736.1

EC 1.6.3.-

EC 1.6.3.1

XP_038285737.1

EC 1.6.3.-

EC 1.6.3.1

XP_038285738.1

EC 1.6.3.-

EC 1.6.3.1

XP_038312131.1

EC 1.6.3.-

EC 1.6.3.1

XP_038312132.1

EC 1.6.3.-

EC 1.6.3.1

XP_038312133.1

EC 1.6.3.-

EC 1.6.3.1

XP_038312134.1

EC 1.6.3.-

EC 1.6.3.1

XP_038361133.1

EC 1.6.3.-

EC 1.6.3.1

XP_038361134.1

EC 1.6.3.-

EC 1.6.3.1

XP_038361135.1

EC 1.6.3.-

EC 1.6.3.1

XP_038361136.1

EC 1.6.3.-

EC 1.6.3.1

XP_038361137.1

EC 1.6.3.-

EC 1.6.3.1

XP_038424277.1

EC 1.6.3.-

EC 1.6.3.1

XP_038424278.1

EC 1.6.3.-

EC 1.6.3.1

XP_038424279.1

EC 1.6.3.-

EC 1.6.3.1

XP_038424280.1

EC 1.6.3.-

EC 1.6.3.1

XP_038488418.1

EC 1.6.3.-

EC 1.6.3.1

XP_038488419.1

EC 1.6.3.-

EC 1.6.3.1

XP_038488420.1

EC 1.6.3.-

EC 1.6.3.1

XP_038488421.1

EC 1.6.3.-

EC 1.6.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051825.1 Reference ROS_Cfam_1.0

Range

10796288..10963304

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038429807.1 → XP_038285735.1 NADPH oxidase 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0NFI8, A0A8I3PVH4

Related

ENSCAFP00845035577.1, ENSCAFT00845045359.1

Conserved Domains (2) summary

cd06186
Location:311 → 577

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 204

Ferric_reduct; Ferric reductase like transmembrane component
XM_038429808.1 → XP_038285736.1 NADPH oxidase 4 isoform X2

UniProtKB/TrEMBL

A0A8C0KW08, A0A8P0TPB8

Conserved Domains (2) summary

cd06186
Location:284 → 550

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 183

Ferric_reduct; Ferric reductase like transmembrane component
XM_038429809.1 → XP_038285737.1 NADPH oxidase 4 isoform X3

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0N1Z8, A0A8P0TR85

Conserved Domains (2) summary

cd06186
Location:274 → 540

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:54 → 167

Ferric_reduct; Ferric reductase like transmembrane component
XM_038429810.1 → XP_038285738.1 NADPH oxidase 4 isoform X4

UniProtKB/TrEMBL

A0A8P0TN90

Conserved Domains (2) summary

cd06186
Location:237 → 503

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:17 → 130

Ferric_reduct; Ferric reductase like transmembrane component

Alternate UMICH_Zoey_3.1

Genomic

NC_049281.1 Alternate UMICH_Zoey_3.1

Range

10584756..10745644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038505205.1 → XP_038361133.1 NADPH oxidase 4 isoform X1

Conserved Domains (2) summary

cd06186
Location:311 → 577

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 204

Ferric_reduct; Ferric reductase like transmembrane component
XM_038505206.1 → XP_038361134.1 NADPH oxidase 4 isoform X2

Conserved Domains (2) summary

cd06186
Location:284 → 550

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 183

Ferric_reduct; Ferric reductase like transmembrane component
XM_038505208.1 → XP_038361136.1 NADPH oxidase 4 isoform X3

Conserved Domains (2) summary

cd06186
Location:274 → 540

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:54 → 167

Ferric_reduct; Ferric reductase like transmembrane component
XM_038505207.1 → XP_038361135.1 NADPH oxidase 4 isoform X5

Conserved Domains (2) summary

cd06186
Location:279 → 545

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:37 → 172

Ferric_reduct; Ferric reductase like transmembrane component
XM_038505209.1 → XP_038361137.1 NADPH oxidase 4 isoform X4

Conserved Domains (2) summary

cd06186
Location:237 → 503

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:17 → 130

Ferric_reduct; Ferric reductase like transmembrane component

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049762.1 Alternate UNSW_CanFamBas_1.0

Range

10643276..10811261

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038632490.1 → XP_038488418.1 NADPH oxidase 4 isoform X1

Conserved Domains (2) summary

cd06186
Location:311 → 577

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 204

Ferric_reduct; Ferric reductase like transmembrane component
XM_038632491.1 → XP_038488419.1 NADPH oxidase 4 isoform X2

Conserved Domains (2) summary

cd06186
Location:284 → 550

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 183

Ferric_reduct; Ferric reductase like transmembrane component
XM_038632492.1 → XP_038488420.1 NADPH oxidase 4 isoform X3

Conserved Domains (2) summary

cd06186
Location:274 → 540

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:54 → 167

Ferric_reduct; Ferric reductase like transmembrane component
XM_038632493.1 → XP_038488421.1 NADPH oxidase 4 isoform X4

Conserved Domains (2) summary

cd06186
Location:237 → 503

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:17 → 130

Ferric_reduct; Ferric reductase like transmembrane component

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049242.1 Alternate UU_Cfam_GSD_1.0

Range

10699999..10861437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038568349.1 → XP_038424277.1 NADPH oxidase 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0NFI8, A0A8I3PVH4

Conserved Domains (2) summary

cd06186
Location:311 → 577

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 204

Ferric_reduct; Ferric reductase like transmembrane component
XM_038568350.1 → XP_038424278.1 NADPH oxidase 4 isoform X2

UniProtKB/TrEMBL

A0A8C0KW08, A0A8P0TPB8

Conserved Domains (2) summary

cd06186
Location:284 → 550

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 183

Ferric_reduct; Ferric reductase like transmembrane component
XM_038568351.1 → XP_038424279.1 NADPH oxidase 4 isoform X3

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0N1Z8, A0A8P0TR85

Conserved Domains (2) summary

cd06186
Location:274 → 540

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:54 → 167

Ferric_reduct; Ferric reductase like transmembrane component
XM_038568352.1 → XP_038424280.1 NADPH oxidase 4 isoform X4

UniProtKB/TrEMBL

A0A8P0TN90

Conserved Domains (2) summary

cd06186
Location:237 → 503

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:17 → 130

Ferric_reduct; Ferric reductase like transmembrane component

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006603.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

10465855..10632710

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038456203.1 → XP_038312131.1 NADPH oxidase 4 isoform X1

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0NFI8, A0A8I3PVH4

Conserved Domains (2) summary

cd06186
Location:311 → 577

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 204

Ferric_reduct; Ferric reductase like transmembrane component
XM_038456204.1 → XP_038312132.1 NADPH oxidase 4 isoform X2

UniProtKB/TrEMBL

A0A8C0KW08, A0A8P0TPB8

Conserved Domains (2) summary

cd06186
Location:284 → 550

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:69 → 183

Ferric_reduct; Ferric reductase like transmembrane component
XM_038456205.1 → XP_038312133.1 NADPH oxidase 4 isoform X3

UniProtKB/TrEMBL

A0A8C0KW08, A0A8C0N1Z8, A0A8P0TR85

Conserved Domains (2) summary

cd06186
Location:274 → 540

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:54 → 167

Ferric_reduct; Ferric reductase like transmembrane component
XM_038456206.1 → XP_038312134.1 NADPH oxidase 4 isoform X4

UniProtKB/TrEMBL

A0A8P0TN90

Conserved Domains (2) summary

cd06186
Location:237 → 503

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:17 → 130

Ferric_reduct; Ferric reductase like transmembrane component