MMACHC metabolism of cobalamin associated C [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MMACHCprovided by VGNC
Official Full Name: metabolism of cobalamin associated Cprovided by VGNC
Primary source: VGNC:VGNC:108229
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (15012610..15018557, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (14978374..14984360, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (14949428..14955416, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (14809847..14815842, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (14877398..14883398, complement)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cyanocobalamin reductase (cyanide-eliminating) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables demethylase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cobalamin metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyanocobalamin reductase / alkylcobalamin dealkylase

Names: methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051819.1 Reference ROS_Cfam_1.0

Range

15012610..15018557 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038687849.1 → XP_038543777.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X2

UniProtKB/TrEMBL

A0A8C0KW24

Conserved Domains (1) summary

pfam16690
Location:13 → 193

MMACHC; Methylmalonic aciduria and homocystinuria type C family
XM_038687848.1 → XP_038543776.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1

UniProtKB/TrEMBL

A0A8C0Z170

Conserved Domains (1) summary

pfam16690
Location:20 → 234

MMACHC; Methylmalonic aciduria and homocystinuria type C family

Alternate UMICH_Zoey_3.1

Genomic

NC_049275.1 Alternate UMICH_Zoey_3.1

Range

14809847..14815842 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038495849.1 → XP_038351777.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X2

Conserved Domains (1) summary

pfam16690
Location:13 → 193

MMACHC; Methylmalonic aciduria and homocystinuria type C family
XM_038495848.1 → XP_038351776.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1

Conserved Domains (1) summary

pfam16690
Location:20 → 234

MMACHC; Methylmalonic aciduria and homocystinuria type C family

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049756.1 Alternate UNSW_CanFamBas_1.0

Range

14877398..14883398 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038622108.1 → XP_038478036.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X2

Conserved Domains (1) summary

pfam16690
Location:13 → 193

MMACHC; Methylmalonic aciduria and homocystinuria type C family
XM_038622106.1 → XP_038478034.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1

Conserved Domains (1) summary

pfam16690
Location:20 → 234

MMACHC; Methylmalonic aciduria and homocystinuria type C family

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049236.1 Alternate UU_Cfam_GSD_1.0

Range

14949428..14955416 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038558232.1 → XP_038414160.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X2

UniProtKB/TrEMBL

A0A8C0KW24

Conserved Domains (1) summary

pfam16690
Location:13 → 193

MMACHC; Methylmalonic aciduria and homocystinuria type C family
XM_038558231.1 → XP_038414159.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1

UniProtKB/TrEMBL

A0A8C0Z170

Conserved Domains (1) summary

pfam16690
Location:20 → 234

MMACHC; Methylmalonic aciduria and homocystinuria type C family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

14978374..14984360 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005629059.4 → XP_005629116.1 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X2

UniProtKB/TrEMBL

A0A8C0KW24

Conserved Domains (1) summary

pfam16690
Location:13 → 193

MMACHC; Methylmalonic aciduria and homocystinuria type C family
XM_539631.7 → XP_539631.2 cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1

UniProtKB/TrEMBL

A0A8C0Z170

Conserved Domains (1) summary

pfam16690
Location:20 → 234

MMACHC; Methylmalonic aciduria and homocystinuria type C family