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    Zfp169 zinc finger protein 169 [ Mus musculus (house mouse) ]

    Gene ID: 67911, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp169provided by MGI
    Official Full Name
    zinc finger protein 169provided by MGI
    Primary source
    MGI:MGI:1915161
    See related
    Ensembl:ENSMUSG00000050954 AllianceGenome:MGI:1915161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700025J14Rik; 4930429A13Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in brain and genitourinary system. Orthologous to human ZNF169 (zinc finger protein 169). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.1), testis adult (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp169 in Genome Data Viewer
    Location:
    13 A5; 13 24.81 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (48634239..48666969, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (48480763..48513493, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34456 Neighboring gene STARR-seq mESC enhancer starr_34457 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_34458 Neighboring gene predicted gene, 40940 Neighboring gene RIKEN cDNA A830005F24 gene Neighboring gene predicted gene, 36402 Neighboring gene STARR-positive B cell enhancer ABC_E7235 Neighboring gene STARR-positive B cell enhancer ABC_E5394 Neighboring gene RIKEN cDNA 6720427I07 gene Neighboring gene microRNA let7d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development. Koerner MV, et al. Epigenomes, 2019 Mar. PMID 31354981, Free PMC Article
    2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 169

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164575.1 → NP_001158047.1  zinc finger protein 169 isoform a

      See identical proteins and their annotated locations for NP_001158047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC060222, CJ110773, CO042325, DV046615
      Consensus CDS
      CCDS26493.2
      UniProtKB/TrEMBL
      E9Q3R6
      Related
      ENSMUSP00000105737.3, ENSMUST00000110110.9
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:255 → 726
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001164576.1 → NP_001158048.1  zinc finger protein 169 isoform b

      See identical proteins and their annotated locations for NP_001158048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK086737, BC060222, CO042325, DV046615
      Consensus CDS
      CCDS49256.1
      UniProtKB/TrEMBL
      G5E912
      Related
      ENSMUSP00000134793.2, ENSMUST00000176176.8
      Conserved Domains (2) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      pfam01352
      Location:14 → 53
      KRAB; KRAB box

    3. NM_026450.3 → NP_080726.3  zinc finger protein 169 isoform a

      See identical proteins and their annotated locations for NP_080726.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK086737, BC060222, CO042325, DV046615
      Consensus CDS
      CCDS26493.2
      UniProtKB/TrEMBL
      E9Q3R6
      Related
      ENSMUSP00000135414.2, ENSMUST00000177530.8
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:255 → 726
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      48634239..48666969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516948.4 → XP_006517011.1  zinc finger protein 169 isoform X2

      See identical proteins and their annotated locations for XP_006517011.1

      UniProtKB/TrEMBL
      E9Q3R6
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:255 → 726
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_017315578.2 → XP_017171067.1  zinc finger protein 169 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:256 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011244411.4 → XP_011242713.1  zinc finger protein 169 isoform X1

      See identical proteins and their annotated locations for XP_011242713.1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:256 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_011244409.3 → XP_011242711.1  zinc finger protein 169 isoform X1

      See identical proteins and their annotated locations for XP_011242711.1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:256 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_011244410.3 → XP_011242712.1  zinc finger protein 169 isoform X1

      See identical proteins and their annotated locations for XP_011242712.1

      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:256 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542 → 562
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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