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    Rimbp3 RIMS binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 239731, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Rimbp3provided by MGI
    Official Full Name
    RIMS binding protein 3provided by MGI
    Primary source
    MGI:MGI:2685449
    See related
    Ensembl:ENSMUSG00000071636 AllianceGenome:MGI:2685449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm603; Gm1759; RIM-BP3; mKIAA1666
    Summary
    Predicted to enable benzodiazepine receptor binding activity. Involved in fertilization and spermatid development. Located in nucleus. Colocalizes with manchette. Orthologous to several human genes including RIMBP3 (RIMS binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Rimbp3 in Genome Data Viewer
    Location:
    16 A3; 16 10.67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17025999..17031846)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17208135..17213982)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17201546-17201655 Neighboring gene predicted gene, 22129 Neighboring gene STARR-seq mESC enhancer starr_40246 Neighboring gene STARR-positive B cell enhancer ABC_E7430 Neighboring gene hypermethylated in cancer 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17276268-17276485 Neighboring gene transmembrane protein 191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RIM-BP3 is a manchette-associated protein essential for spermiogenesis. Zhou J, et al. Development, 2009 Feb. PMID 19091768
    2. Structure and evolution of RIM-BP genes: identification of a novel family member. Mittelstaedt T, et al. Gene, 2007 Nov 15. PMID 17855024
    3. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables benzodiazepine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with manchette IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RIMS-binding protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033338.3 → NP_001028510.2  RIMS-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AA030140, AC154667, AK133200, BG075083
      Consensus CDS
      CCDS27998.2
      UniProtKB/Swiss-Prot
      B9EJ89, E9PZY2, Q3V0F0, Q5DTW0
      Related
      ENSMUSP00000127909.2, ENSMUST00000169803.5
      Conserved Domains (3) summary
      smart00060
      Location:982 → 1043
      FN3; Fibronectin type 3 domain
      TIGR02168
      Location:29 → 671
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17036
      Location:826 → 886
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17025999..17031846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0F0.2 GenPept UniProtKB/Swiss-Prot:Q3V0F0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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