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    HSPG2 heparan sulfate proteoglycan 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 707213, updated on 5-Mar-2024

    Summary

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    Official Symbol
    HSPG2provided by VGNC
    Official Full Name
    heparan sulfate proteoglycan 2provided by VGNC
    Primary source
    VGNC:VGNC:73534
    See related
    Ensembl:ENSMMUG00000014828
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HSPG2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    103
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (202851088..202941372)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (20608894..20684930, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114673955 Neighboring gene U6 spliceosomal RNA Neighboring gene chymotrypsin like elastase 3B Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene U7 small nuclear RNA Neighboring gene RAP1 GTPase activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basement membrane-specific heparan sulfate proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      202851088..202941372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015130367.2 → XP_014985853.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X7

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:481 → 558
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1832 → 1917
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 254
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1046 → 1173
      LamB; Laminin B domain
      smart00409
      Location:2993 → 3070
      IG; Immunoglobulin
      smart00410
      Location:2118 → 2195
      IG_like; Immunoglobulin like
      cd00054
      Location:3913 → 3942
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1219 → 1268
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4264 → 4423
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:385 → 419
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4169 → 4199
      EGF; EGF-like domain
      pfam00053
      Location:1336 → 1383
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:257 → 294
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3642 → 3719
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3478 → 3544
      Ig; Immunoglobulin domain

    2. XM_028838327.1 → XP_028694160.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:498 → 575
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1999 → 2084
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 253
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1063 → 1190
      LamB; Laminin B domain
      smart00409
      Location:2479 → 2553
      IG; Immunoglobulin
      smart00410
      Location:2285 → 2362
      IG_like; Immunoglobulin like
      cd00054
      Location:4086 → 4115
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1236 → 1285
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4437 → 4596
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:402 → 436
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4342 → 4372
      EGF; EGF-like domain
      pfam00053
      Location:1353 → 1400
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:274 → 311
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3809 → 3886
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3645 → 3711
      Ig; Immunoglobulin domain

    3. XM_028838335.1 → XP_028694168.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X4

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:498 → 575
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1999 → 2084
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 253
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1063 → 1190
      LamB; Laminin B domain
      smart00409
      Location:2479 → 2553
      IG; Immunoglobulin
      smart00410
      Location:2285 → 2362
      IG_like; Immunoglobulin like
      cd00054
      Location:4080 → 4109
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1236 → 1285
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4431 → 4590
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:402 → 436
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4336 → 4366
      EGF; EGF-like domain
      pfam00053
      Location:1353 → 1400
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:274 → 311
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3809 → 3886
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3645 → 3711
      Ig; Immunoglobulin domain

    4. XM_028838332.1 → XP_028694165.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:498 → 575
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1999 → 2084
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 253
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1063 → 1190
      LamB; Laminin B domain
      smart00409
      Location:2479 → 2553
      IG; Immunoglobulin
      smart00410
      Location:2285 → 2362
      IG_like; Immunoglobulin like
      cd00054
      Location:4084 → 4113
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1236 → 1285
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4435 → 4594
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:402 → 436
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4340 → 4370
      EGF; EGF-like domain
      pfam00053
      Location:1353 → 1400
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:274 → 311
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3807 → 3884
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3643 → 3709
      Ig; Immunoglobulin domain

    5. XM_028838345.1 → XP_028694178.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X6

      UniProtKB/TrEMBL
      G7MHF2
      Related
      ENSMMUP00000019469.4, ENSMMUT00000020806.4
      Conserved Domains (15) summary
      cd05743
      Location:498 → 575
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1849 → 1934
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 253
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1063 → 1190
      LamB; Laminin B domain
      smart00409
      Location:3010 → 3087
      IG; Immunoglobulin
      smart00410
      Location:2135 → 2212
      IG_like; Immunoglobulin like
      cd00054
      Location:3936 → 3965
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1236 → 1285
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4287 → 4446
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:402 → 436
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4192 → 4222
      EGF; EGF-like domain
      pfam00053
      Location:1353 → 1400
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:274 → 311
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3659 → 3736
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3495 → 3561
      Ig; Immunoglobulin domain

    6. XM_028838329.1 → XP_028694162.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:498 → 575
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1998 → 2083
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 253
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1062 → 1189
      LamB; Laminin B domain
      smart00409
      Location:2478 → 2552
      IG; Immunoglobulin
      smart00410
      Location:2284 → 2361
      IG_like; Immunoglobulin like
      cd00054
      Location:4085 → 4114
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1235 → 1284
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4436 → 4595
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:402 → 436
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4341 → 4371
      EGF; EGF-like domain
      pfam00053
      Location:1352 → 1399
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:274 → 311
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3808 → 3885
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3644 → 3710
      Ig; Immunoglobulin domain

    7. XM_028838340.1 → XP_028694173.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X5

      UniProtKB/TrEMBL
      G7MHF2
      Conserved Domains (15) summary
      cd05743
      Location:481 → 558
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1982 → 2067
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 254
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1046 → 1173
      LamB; Laminin B domain
      smart00409
      Location:2462 → 2536
      IG; Immunoglobulin
      smart00410
      Location:2268 → 2345
      IG_like; Immunoglobulin like
      cd00054
      Location:4069 → 4098
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1219 → 1268
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4420 → 4579
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:385 → 419
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4325 → 4355
      EGF; EGF-like domain
      pfam00053
      Location:1336 → 1383
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:257 → 294
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3792 → 3869
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3628 → 3694
      Ig; Immunoglobulin domain

    8. XM_015130373.2 → XP_014985859.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X8

      UniProtKB/TrEMBL
      G7MHF2
      Related
      ENSMMUP00000040540.3, ENSMMUT00000047505.3
      Conserved Domains (15) summary
      cd05743
      Location:481 → 558
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:1831 → 1916
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00200
      Location:140 → 254
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00281
      Location:1045 → 1172
      LamB; Laminin B domain
      smart00409
      Location:2992 → 3069
      IG; Immunoglobulin
      smart00410
      Location:2117 → 2194
      IG_like; Immunoglobulin like
      cd00054
      Location:3912 → 3941
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:1218 → 1267
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:4263 → 4422
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:385 → 419
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00008
      Location:4168 → 4198
      EGF; EGF-like domain
      pfam00053
      Location:1335 → 1382
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:257 → 294
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:3641 → 3718
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:3477 → 3543
      Ig; Immunoglobulin domain
    Nucleotide Protein
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