Dnai2 dynein axonemal intermediate chain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnai2provided by MGI
Official Full Name: dynein axonemal intermediate chain 2provided by MGI
Primary source: MGI:MGI:2685574
See related: Ensembl:ENSMUSG00000034706 AllianceGenome:MGI:2685574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm728; Dnaic2; b2b3405Clo; C030015H18Rik
Summary: Predicted to enable dynein heavy chain binding activity; dynein light chain binding activity; and microtubule motor activity. Predicted to be involved in cilium movement; determination of left/right symmetry; and outer dynein arm assembly. Predicted to act upstream of or within cilium assembly. Located in 9+2 motile cilium; axoneme; and external side of plasma membrane. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 13.1), ovary adult (RPKM 3.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.19 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114614634..114648715)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114721341..114757889)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dnaic2 plays a role in oogenesis and spermatogenesis by activation of Stat3.
Title: Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3.
Results obtained with Western blot analysis revealed that the expression of DNAI2 protein was significantly less in oviducts of dNOD mice as compared to that of cNOD mice corroborating the results obtained with immunohistochemistry
Title: Alterations in oviductal cilia morphology and reduced expression of axonemal dynein in diabetic NOD mice.
These data suggest that Dnaic2 plays a role in ovarian follicular development.
Title: Mouse dynein axonemal intermediate chain 2: cloning and expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IDA Inferred from Direct Assay more info	PubMed
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in axoneme	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of outer dynein arm	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal intermediate chain 2

Names: dynein intermediate chain 2, axonemal; dynein, axonemal, intermediate polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034878.3 → NP_001030050.2 dynein axonemal intermediate chain 2

See identical proteins and their annotated locations for NP_001030050.2

Status: VALIDATED

Source sequence(s)

AK081229, AK138639, AL663079, BB867928, BE946605, BM950889, CJ049712

Consensus CDS

CCDS36366.1

UniProtKB/Swiss-Prot

A2AC93, A2AC94

UniProtKB/TrEMBL

R4GML5

Related

ENSMUSP00000065787.8, ENSMUST00000069325.14

Conserved Domains (2) summary

COG2319
Location:166 → 495

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 212

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114614634..114648715

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533660.4 → XP_006533723.1 dynein axonemal intermediate chain 2 isoform X1

See identical proteins and their annotated locations for XP_006533723.1

UniProtKB/Swiss-Prot

A2AC93, A2AC94

UniProtKB/TrEMBL

R4GML5

Conserved Domains (2) summary

COG2319
Location:166 → 495

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 212

7WD40; WD40 repeat [structural motif]
XM_036156823.1 → XP_036012716.1 dynein axonemal intermediate chain 2 isoform X1

UniProtKB/Swiss-Prot

A2AC93, A2AC94

UniProtKB/TrEMBL

R4GML5

Conserved Domains (2) summary

COG2319
Location:166 → 495

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 212

7WD40; WD40 repeat [structural motif]
XM_006533661.2 → XP_006533724.1 dynein axonemal intermediate chain 2 isoform X1

See identical proteins and their annotated locations for XP_006533724.1

UniProtKB/Swiss-Prot

A2AC93, A2AC94

UniProtKB/TrEMBL

R4GML5

Related

ENSMUSP00000090126.5, ENSMUST00000092469.11

Conserved Domains (2) summary

COG2319
Location:166 → 495

WD40; WD40 repeat [General function prediction only]

sd00039
Location:165 → 212

7WD40; WD40 repeat [structural motif]
XM_006533663.3 → XP_006533726.1 dynein axonemal intermediate chain 2 isoform X2

Conserved Domains (3) summary

COG2319
Location:16 → 414

WD40; WD40 repeat [General function prediction only]

sd00039
Location:38 → 85

7WD40; WD40 repeat [structural motif]

pfam11600
Location:409 → 485

CAF-1_p150; Chromatin assembly factor 1 complex p150 subunit, N-terminal