Fhl1 four and a half LIM domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fhl1provided by RGD
Official Full Name: four and a half LIM domains 1provided by RGD
Primary source: RGD:2615
See related: Ensembl:ENSRNOG00000000875 AllianceGenome:RGD:2615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SLIM1
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Predicted to be located in cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 6067.5), Lung (RPKM 1888.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (139592794..139652290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (134555399..134614930)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (159112516..159172528)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FHL1 may be involved in excessive cell proliferation and may represent a potential therapeutic target for pulmonary hypertension.
Title: Inhibition of FHL1 inhibits cigarette smoke extract-induced proliferation in pulmonary arterial smooth muscle cells.
FHL1 exists as part of a complex, which binds gamma-actin and non-muscle myosin IIB
Title: Identification of an FHL1 protein complex containing gamma-actin and non-muscle myosin IIB by analysis of protein-protein interactions.
Hypoxia-induced downregulation of miR-206 promotes pulmonary hypertension by targeting the HIF-1alpha/Fhl-1 pathway in pulmonary artery smooth muscle cells.
Title: MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension through targeting of the HIF-1α/Fhl-1 pathway.
FHL1 knockdown significantly inhibited the proliferation of rat aortic smooth muscle cells but exerted no obvious effect on cell apoptosis.
Title: Downregulation of FHL1 expression in thoracic aortic dissection: implications in aortic wall remodeling and pathogenesis of thoracic aortic dissection.
These data indicate that estradiol down-regulates Fhl1 expression through its binding to the ERbeta.
Title: Transcriptional regulation of Fhl1 by estradiol in rat myoblastocytes.
Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Title: Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Over-production of SLIM1 in the cells resulted in a change in the cell-shape into a spindle-like form.
Title: Up-regulation of skeletal muscle LIM protein 1 gene by 25-hydroxycholesterol may mediate morphological changes of rat aortic smooth muscle cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI556806 (e-PCR)
- UniSTS:244738

Fhl1 (e-PCR), detects polymorphism
- UniSTS:506893

Fhl1 (e-PCR), detects polymorphism
- UniSTS:472852

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: four and a half LIM domains protein 1

Names: FHL-1; skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033926.2 → NP_001029098.1 four and a half LIM domains protein 1 isoform 1

See identical proteins and their annotated locations for NP_001029098.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC061782, CK840296, FQ119120

UniProtKB/TrEMBL

A0A8I6A745, Q6P792

Conserved Domains (5) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:233 → 296

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:178 → 230

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001271199.1 → NP_001258128.1 four and a half LIM domains protein 1 isoform 3

See identical proteins and their annotated locations for NP_001258128.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains 2 alternate exons at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (3) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

AF134773, BC061782, CK840296, JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9WUH4

UniProtKB/TrEMBL

A0A8I6A745, A6KSP3

Related

ENSRNOP00000074052.1, ENSRNOT00000084594.2

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001271200.1 → NP_001258129.1 four and a half LIM domains protein 1 isoform 3

See identical proteins and their annotated locations for NP_001258129.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (3) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.

Source sequence(s)

BC061782, CK477468, CK840296, FM042472

UniProtKB/Swiss-Prot

Q9WUH4

UniProtKB/TrEMBL

A0A8I6A745, A6KSP3

Related

ENSRNOP00000088085.1, ENSRNOT00000110431.1

Conserved Domains (5) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09348
Location:217 → 280

LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001271201.1 → NP_001258130.1 four and a half LIM domains protein 1 isoform 4

See identical proteins and their annotated locations for NP_001258130.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate exon at the 5' end and lacks an exon in the 3' coding region compared to variant 1, which results in an isoform (4) with a shorter N-terminus and a distinct C-terminus compared to isoform 1.

Source sequence(s)

BC061782, CK840296, FM042472

UniProtKB/TrEMBL

A6KSP7

Conserved Domains (3) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_145669.3 → NP_663702.1 four and a half LIM domains protein 1 isoform 2

See identical proteins and their annotated locations for NP_663702.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.

Source sequence(s)

AY115564, BC061782, CK840296, FQ119120

UniProtKB/TrEMBL

F8WFH4, Q8K3G3

Related

ENSRNOP00000001169.5, ENSRNOT00000001169.7

Conserved Domains (3) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

139592794..139652290

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257672.5 → XP_006257734.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006257734.1

UniProtKB/TrEMBL

A0A8L2R9G0, A6KSP6

Related

ENSRNOP00000049677.4

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006257676.5 → XP_006257738.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006257738.1

UniProtKB/TrEMBL

A0A8L2R9G0, A6KSP6

Related

ENSRNOP00000074817.2

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006257674.5 → XP_006257736.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006257736.1

UniProtKB/TrEMBL

A0A8L2R9G0, A6KSP6

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006257673.4 → XP_006257735.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006257735.1

UniProtKB/TrEMBL

A0A8L2R9G0, A6KSP6

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006257671.5 → XP_006257733.1 four and a half LIM domains protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K338, A0A8L2R9G0

Related

ENSRNOP00000072490.1

Conserved Domains (4) summary

cd09344
Location:56 → 109

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:117 → 174

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:178 → 230

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:21 → 49

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006257675.5 → XP_006257737.1 four and a half LIM domains protein 1 isoform X2

See identical proteins and their annotated locations for XP_006257737.1

UniProtKB/TrEMBL

A0A8L2R9G0, A6KSP6

Conserved Domains (4) summary

cd09344
Location:40 → 93

LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1

cd09424
Location:101 → 158

LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)

cd09429
Location:162 → 214

LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)

cl02475
Location:5 → 33

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers